Informace o projektu
Structure-functional Relationships of Haloalkane Dehalogenases
- Kód projektu
- GAP207/12/0775
- Období řešení
- 1/2012 - 12/2016
- Investor / Programový rámec / typ projektu
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Grantová agentura ČR
- Standardní projekty
- Fakulta / Pracoviště MU
- Přírodovědecká fakulta
- Spolupracující organizace
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Jihočeská univerzita v Českých Budějovicích
Proposed project is continuation of a very productive cooperation between the Institute of Physical Biology University of South Bohemia and the Loschmidt Laboratories at Masaryk University. This cooperation has started in 2006 within the project of Centre for Biocatalysis and Biotransformation LC06010 supported by the Czech Ministry of Education. This project has yielded 7 joint impacted publications and more than 30 conference contributions during the past 6 years. Moreover, 5 Ph.D. theses will be finished during 2010-2013. To keep high standard for this running collaboration, we would like to continue with the research project in the framework of GACR project named “Structure-Functional Relationships of Haloalkane Dehalogenases“.
Publikace
Počet publikací: 23
2017
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Kinetics of Binding of Fluorescent Ligands to Enzymes with Engineered Access Tunnels
FEBS Journal, rok: 2017, ročník: 284, vydání: 1, DOI
2016
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Engineering a de Novo Transport Tunnel
ACS Catalysis, rok: 2016, ročník: 6, vydání: 11, DOI
2015
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Balancing the Stability-Activity Trade-off by Fine-Tuning Dehalogenase Access Tunnels.
ChemCatChem, rok: 2015, ročník: 7, vydání: 4, DOI
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Instability restricts signaling of multiple fibroblast growth factors
Cellular and Molecular Life Sciences, rok: 2015, ročník: 72, vydání: 12, DOI
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Site-specific Analysis of Protein Hydration Based on Unnatural Amino Acid Fluorescence.
Journal of the American Chemical Society, rok: 2015, ročník: 137, vydání: 15, DOI
2014
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Comparison of Catalysis by Haloalkane Dehalogenases in Aqueous Solutions of a Deep Eutectic and Organic Solvents.
Green Chemistry, rok: 2014, ročník: 16, vydání: 5, DOI
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Crystallographic Analysis of 1,2,3–Trichloropropane Biodegradation by Haloalkane Dehalogenase DhaA31
Acta Crystallographica D, rok: 2014, ročník: 70, vydání: february, DOI
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Microscopic Monitoring Provides Information on Structure and Properties During Biocatalyst Immobilisation.
Biotechnology Journal, rok: 2014, ročník: 9, vydání: 6, DOI
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Structural and Functional Analysis of a Novel Haloalkane Dehalogenase with Two Halide-Binding Sites.
Acta Crystallographica D, rok: 2014, ročník: 70, vydání: July, DOI
2013
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Are Time-Dependent Fluorescence Shifts at the Tunnel Mouth of Haloalkane Dehalogenase Enzymes Dependent on the Choice of the Chromophore?
Journal of Physical Chemistry B, rok: 2013, ročník: 117, vydání: 26, DOI