Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2018127
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
-
Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
-
Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
- Spolupracující organizace
-
Biotechnologický ústav AV ČR, v.v.i.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 182
2023
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Proteotype classification of localized and metastatic renal cell carcinoma for prognosis and therapy response
Rok: 2023, druh: Konferenční abstrakty
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Proteotype classification of metastatic and localized renal cell carcinomas for prognosis and therapy response
Rok: 2023, druh: Konferenční abstrakty
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Pseudomonas petrae sp. nov. isolated from regolith samples in Antarctica
Systematic and Applied Microbiology, rok: 2023, ročník: 46, vydání: 4, DOI
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Puncturing lipid membranes: onset of pore formation and the role of hydrogen bonding in the presence of flavonoids
JOURNAL OF LIPID RESEARCH, rok: 2023, ročník: 64, vydání: 10, DOI
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Single-particle infrared laser ablation ICP MS for digital imaging of 3D cell aggregates
Rok: 2023, druh: Konferenční abstrakty
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Staphylococcus aureus Prophage-Encoded Protein Causes Abortive Infection and Provides Population Immunity against Kayviruses
mBio, rok: 2023, ročník: 14, vydání: 2, DOI
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Synthesis and Antiviral Activity of 2′-Modified L-Nucleoside Analogues.
ChemistrySelect, rok: 2023, ročník: 8, vydání: 48, DOI
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Targeting undruggable oncoproteins c-Myc and N-Myc by the 9aaTADs
Rok: 2023, druh: Další prezentace na konferencích
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Tick-borne encephalitis: A comprehensive review of the epidemiology, virology, and clinical picture
Reviews in Medical Virology, rok: 2023, ročník: 33, vydání: 5, DOI
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Unveiling the nanotoxicological aspects of Se nanomaterials differing in size and morphology
BIOACTIVE MATERIALS, rok: 2023, ročník: 20, vydání: FEB, DOI