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Gates of Enzymes.

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GORA Artur Wiktor BREZOVSKÝ Jan DAMBORSKÝ Jiří

Rok publikování 2013
Druh Článek v odborném periodiku
Časopis / Zdroj Chemical Reviews
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
Doi http://dx.doi.org/10.1021/cr300384w
Obor Biochemie
Klíčová slova haloalkane dehalogenases
Popis This review highlights the importance of gates in enzymes. The gates control substrate access to the active site and product release, restrict solvent access to specific protein regions, and synchronize processes occurring in distinct parts of the enzyme. Survey of 129 gates in 71 enzymes enabled a rigorous definition of gates and establishment of a new scheme for their classification. Gates were assigned to six distinct classes – wings, swinging doors, apertures, drawbridges, double drawbridges and shells. Presented are summary statistics describing the propensity of specific amino acid residues in particular gate classes. The proposed classification scheme provides guidance for the analysis and engineering of gates in biomolecular systems.
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