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The Association Study of DRD2, ACE and AGT Gene Polymorphisms and Metamphetamine Dependence
Autoři | |
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Rok publikování | 2001 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Physiological Research |
Fakulta / Pracoviště MU | |
Citace | |
Obor | Fyziologie |
Klíčová slova | TaqI A polymorphism; DRD2; ACE; M235T; Angiotensinogen; Metamphetamine dependence |
Popis | We investigated for the first time the association between the metamphetamine dependence and TaqI A polymorphism of the dopamine receptor D2 gene, I/D ACE polymorphism and M235T polymorphism of the angiotensinogen gene (AGT) in 93 unrelated metamphetamine dependent subjects and 131 controls. Our results did not prove any association of the TaqI A polymorphism of the DRD2 gene, I/D polymorphism of ACE gene and M235T polymorphism of AGT gene with the metamphetamine dependence in Caucasians of Czech origin, however, a statistically significant difference in I allele frequency between male control and female control groups for the I/D ACE polymorphism (p<0.03) was found. |
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