Publication details

The Association Study of DRD2, ACE and AGT Gene Polymorphisms and Metamphetamine Dependence

Authors

ŠERÝ Omar VOJTOVÁ Veronika ZVOLSKÝ Petr

Year of publication 2001
Type Article in Periodical
Magazine / Source Physiological Research
MU Faculty or unit

Faculty of Science

Citation
Field Physiology
Keywords TaqI A polymorphism; DRD2; ACE; M235T; Angiotensinogen; Metamphetamine dependence
Description We investigated for the first time the association between the metamphetamine dependence and TaqI A polymorphism of the dopamine receptor D2 gene, I/D ACE polymorphism and M235T polymorphism of the angiotensinogen gene (AGT) in 93 unrelated metamphetamine dependent subjects and 131 controls. Our results did not prove any association of the TaqI A polymorphism of the DRD2 gene, I/D polymorphism of ACE gene and M235T polymorphism of AGT gene with the metamphetamine dependence in Caucasians of Czech origin, however, a statistically significant difference in I allele frequency between male control and female control groups for the I/D ACE polymorphism (p<0.03) was found.
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