Informace o publikaci

Reversibility of cadmium-induced apoptosis is associated with increased level of telomerase activity in tobacco TBY-2 cells

Autoři

FOJTOVÁ Miloslava FULNEČKOVÁ Jana FAJKUS Jiří KOVAŘÍK Aleš

Rok publikování 2001
Druh Článek ve sborníku
Konference Journal of Biomolecular Structure and Dynamics
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
Obor Biofyzika
Klíčová slova cadmium-induced apoptosis; tobacco
Popis To monitor apoptotic changes, we followed several parameters including cell viability, DNA integrity and telomerase activity.Preapoptotic phase has been achieved by exposure of cells to 50mM cadmium for 3 days.At that time the cell culture retains more than 95% viability although the majority of DNA is fragmented into 50-200 kb.Integrity of DNA is reestablished within two days after cadmium removal suggesting that an efficient DNA repair process has occurred.In parallel, a significant increase of telomerase activity in cell extracts is observed.The data suggest an involvement of telomerase in plant chromosome healing in response to damage caused by genotoxic agents.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info