Informace o publikaci
Low content of mitochondrial ATPase in brown adipose tissue is the result of post-transcriptional regulation
| Autoři | |
|---|---|
| Rok publikování | 1991 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | FEBS Letters [IF=3.479 (1990); SCI #cit.<22>] |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Genetika a molekulární biologie |
| Klíčová slova | ATPase; brown adipose tissue; cytochrome oxidase; mitochondrion; nuclear gene; transcription |
| Popis | The mRNA levels of ATPase beta, ATPase 6, cytochrome oxidase (COX) VIb and COX I subunits were found to be 2.4-13.8-fold higher in brown adipose tissue (BAT) than in heart, skeletal muscle, brain and liver of mice. The comparison with tissue contents of ATPase and COX revealed that the selective, 5-11-fold reduction of ATPase in BAT is not caused by decreased transcription of ATPase genes. The results indicate that the biosynthesis of mitochondrial ATPase in BAT is post-transcriptionally regulated. |