Publication details
Low content of mitochondrial ATPase in brown adipose tissue is the result of post-transcriptional regulation
| Authors | |
|---|---|
| Year of publication | 1991 |
| Type | Article in Periodical |
| Magazine / Source | FEBS Letters [IF=3.479 (1990); SCI #cit.<22>] |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | ATPase; brown adipose tissue; cytochrome oxidase; mitochondrion; nuclear gene; transcription |
| Description | The mRNA levels of ATPase beta, ATPase 6, cytochrome oxidase (COX) VIb and COX I subunits were found to be 2.4-13.8-fold higher in brown adipose tissue (BAT) than in heart, skeletal muscle, brain and liver of mice. The comparison with tissue contents of ATPase and COX revealed that the selective, 5-11-fold reduction of ATPase in BAT is not caused by decreased transcription of ATPase genes. The results indicate that the biosynthesis of mitochondrial ATPase in BAT is post-transcriptionally regulated. |