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Informace o publikaci
Mutp53 non-B DNA structure binding to intronic sequences modulates gene expression in U251 cells
Název česky | Vazba non-B DNA struktury mutp53 na intronové sekvence moduluje expresi genů v buňkách U251 |
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Autoři | |
Rok publikování | 2009 |
Druh | Konferenční abstrakty |
Fakulta / Pracoviště MU | |
Citace | |
Popis | Missense point mutations in the TP53 gene are frequent genetic alterations in human tumor tissue and cell lines derived thereof. Mutant p53 (mutp53) proteins have lost sequence-specific DNA binding, but have retained the ability to interact in a structure-selective manner with non-B DNA and to act as regulators of transcription. We propose a model that attributes the oncogenic functions of mutp53 to its ability to interact with intronic and intergenic non-B DNA sequences and modulate gene transcription via re-organization of chromatin. |
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