Mutp53 non-B DNA structure binding to intronic sequences modulates gene expression in U251 cells

• Název česky: Vazba non-B DNA struktury mutp53 na intronové sekvence moduluje expresi genů v buňkách U251
• Autoři: TICHÝ V.; BRÁZDOVÁ Marie; QUANTE T.; TOGEL L.; WALTER K.; LOSCHER G.; NAVRATILOVA L.; LEXA Matej; DEPPERT W.; TOLSTONOG G.V.
• Rok publikování: 2009
• Druh: Konferenční abstrakty
• Fakulta / Pracoviště MU: Fakulta informatiky
• Popis: Missense point mutations in the TP53 gene are frequent genetic alterations in human tumor tissue and cell lines derived thereof. Mutant p53 (mutp53) proteins have lost sequence-specific DNA binding, but have retained the ability to interact in a structure-selective manner with non-B DNA and to act as regulators of transcription. We propose a model that attributes the oncogenic functions of mutp53 to its ability to interact with intronic and intergenic non-B DNA sequences and modulate gene transcription via re-organization of chromatin.

Související projekty

• Bioinformatická a experimentální identifikace nekanonických struktur v genomové DNA