doc. Mgr. Kamil Paruch, Ph.D.

2024

• Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2

  NĚMEC Václav REMEŠ Marek BEŇOVSKÝ Petr BÖCK Michael Christopher ŠRANKOVÁ Eliška WONG Jong Fu JULIEN Cros WILLIAMS Eleanor TSE Lap Hang SMIL David ENSAN Deeba ISAAC Methvin B AL-AWAR Rima GOMOLKOVÁ Regína URSACHI Vlad-Constantin FAFÍLEK Bohumil KAHOUNOVA Zuzana VICHOVA Rachel VACEK Ondrej BERGER Benedict-Tilman WELLS Carrow I CORONA Cesear R VASTA James D ROBERS Matthew B KREJČÍ Pavel SOUČEK Karel BULLOCK Alex N KNAPP Stefan PARUCH Kamil

  Article in Periodical

  Journal of Medicinal Chemistry, year: 2024, volume: 67, edition: 15, DOI

• IDENTIFICATION OF NOVEL CYTOKININS BY MOLECULAR DOCKING

  PUSHKAROVA Nadiia HENNELOVA Jana MARQUES Sérgio Manuel BEDNÁŘ David PARUCH Kamil AKAVARAM Naresh SPICHAL L. DAMBORSKÝ Jiří YEMETS A. HEJÁTKO Jan

  Conference abstract

  Year: 2024, type: Conference abstract

• Inhibition of Chk1 stimulates cytotoxic action of platinum-based drugs and TRAIL combination in human prostate cancer cells

  KRKOŠKA Martin PARUCH Kamil ŠOŠOLÍKOVÁ Tereza VÁZQUEZ-GÓMEZ Gerardo HERŮDKOVÁ Jarmila NOVOTNÝ Jan OVESNÁ Petra SOVA Petr HYRŠLOVÁ VACULOVÁ Alena

  Article in Periodical

  Biological Chemistry, year: 2024, volume: 405, edition: 6, DOI

• Unexpectedly Regioselective Diels-Alder Reactions of New Unsymmetrical Benzoquinones: A Convenient Synthetic Entry to Uniquely Substituted Decalins

  MAIER Lukáš NĚMEČKOVÁ Dana AKAVARAM Naresh KALLA Erik SEMRÁD Hugo MATYASKOVÁ Olivie MUNZAROVÁ Markéta DAĎOVÁ Petra KUBALA Lukáš ŠVENDA Jakub PARUCH Kamil

  Article in Periodical

  Chemistry - A European Journal, year: 2024, volume: 30, edition: 55, DOI

2023

• 4-(1H-IMIDAZOL-5-YL)-1H-PYRROLO [2,3-B] PYRIDINES FOR USE IN THE TREATMENT OF LEUKAEMIAS, LYMPHOMAS AND SOLID TUMORS

  BRYJA Vítězslav JANOVSKÁ Pavlína GREGOROVÁ Michaela NĚMEC Václav KHIRSARIYA PrashantKumar PARUCH Kamil

  Patent

  Publisher: China National Intellectual Property Administration, state: China, patent's number: CN111936496, year: 2023

• Convergent Assembly of the Tricyclic Labdane Core Enables Synthesis of Diverse Forskolin-like Molecules

  SZCZEPANIK Pawel Marcin MIKHAYLOV Andrey HYLSE Ondřej KUČERA Roman DAĎOVÁ Petra NEČAS Marek KUBALA Lukáš PARUCH Kamil ŠVENDA Jakub

  Article in Periodical

  Angewandte Chemie International Edition, year: 2023, volume: 62, edition: 1, DOI

• Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity

  NĚMEC Václav KHIRSARIYA PrashantKumar JANOVSKÁ Pavlína MARTÍN MOYANO Paula MAIER Lukáš PROCHÁZKOVÁ Petra KEBKOVÁ Pavlína GYBEĽ Tomáš BERGER Benedict-Tilman CHAIKUAD Apirat REINECKE Maria KUSTER Bernhard KNAPP Stefan BRYJA Vítězslav PARUCH Kamil

  Article in Periodical

  Angewandte Chemie International Edition, year: 2023, volume: 62, edition: 11, DOI

• Substituted aminothiazoles as inhibitors of nucleases

  PARUCH Kamil CARBAIN Benoit Jean-Pierre HAVEL Štěpán DAMBORSKÝ Jiří BREZOVSKÝ Jan DANIEL Lukáš SISÁKOVÁ Alexandra NIKULENKOV Fedor KREJČÍ Lumír

  Patent

  Publisher: United States Patent and Trademark Office, state: United States of America, patent's number: US11584742, year: 2023

• Substituted aminothiazoles as inhibitors of nucleases

  PARUCH Kamil CARBAIN Benoit Jean-Pierre HAVEL Štěpán DAMBORSKÝ Jiří BREZOVSKÝ Jan DANIEL Lukáš SISÁKOVÁ Alexandra NIKULENKOV Fedor KREJČÍ Lumír

  Patent

  Publisher: Israel Patent Office, state: Israel, patent's number: IL277866, year: 2023

2022

• 4-(1h- imidazol- 5- yl) -1h-pyrrolo [2, 3-b] pyridines for use in the treatment of leukaemias, lymphomas and solid tumors

  BRYJA Vítězslav JANOVSKÁ Pavlína GREGOROVÁ Michaela NĚMEC Václav KHIRSARIYA PrashantKumar PARUCH Kamil

  Patent

  Publisher: Canadian Intellectual Property Office, state: Canada, patent's number: CA3085967, year: 2022