doc. Mgr. Kamil Paruch, Ph.D.

2022

• Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides

  KHIRSARIYA PrashantKumar POSPÍŠIL Patrik MAIER Lukáš BOUDNÝ Miroslav BABÁŠ Martin KROUTIL Ondřej MRÁZ Marek VÁCHA Robert PARUCH Kamil

  Article in Periodical

  Journal of Medicinal Chemistry, year: 2022, volume: 65, edition: 7, DOI

• ヌクレアーゼの阻害剤としての置換アミノチアゾール

  PARUCH Kamil CARBAIN Benoit Jean-Pierre HAVEL Štěpán DAMBORSKÝ Jiří BREZOVSKÝ Jan DANIEL Lukáš SISÁKOVÁ Alexandra NIKULENKOV Fedor KREJČÍ Lumír

  Patent

  Publisher: Japan Patent Office (JPO), state: Japan, patent's number: JP7175031, year: 2022

• ヌクレアーゼの阻害剤としての置換プロパンアミド

  PARUCH Kamil CARBAIN Benoit Jean-Pierre HAVEL Štěpán VŠIANSKÝ Vít NIKULENKOV Fedor KREJČÍ Lumír

  Patent

  Publisher: Japan Patent office, state: Japan, patent's number: JP7148999, year: 2022

• 백혈병, 림프종 및 고형 종양의 치료에 사용하기 위한 4-(1H-이미다졸-5-일)-1H-피롤로[2,3-b]피리딘

  BRYJA Vítězslav JANOVSKÁ Pavlína GREGOROVÁ Michaela NĚMEC Václav KHIRSARIYA PrashantKumar PARUCH Kamil

  Patent

  Publisher: Korean Intellectual Property Office, state: Korea, Republic of, patent's number: KR10-2465111, year: 2022

• 白血病、リンパ腫および固形腫瘍の治療に使用するための４－（１Ｈ－イミダゾール－５－イル）－１Ｈ－ピロロ［２，３－ｂ］ピリジン

  BRYJA Vítězslav JANOVSKÁ Pavlína GREGOROVÁ Michaela NĚMEC Václav KHIRSARIYA PrashantKumar PARUCH Kamil

  Patent

  Publisher: Japan Patent Office, state: Japan, patent's number: JP7008967, year: 2022

2021

• 4—(1h— imidazol— 5— yl) -1h-pyrrolo (2, 3-b) pyridines for use in the treatment of leukaemias, lymphomas and solid tumors

  BRYJA Vítězslav JANOVSKÁ Pavlína GREGOROVÁ Michaela NĚMEC Václav KHIRSARIYA PrashantKumar PARUCH Kamil

  Patent

  Publisher: The Australian Patents Register, state: Australia, patent's number: AU 2019246220, year: 2021

• Cytoprotective activities of kinetin purine isosteres

  MAKOVÁ Barbara MIK Václav LIŠKOVÁ Barbora GONZALEZ Gabriel VÍTEK Dominik MEDVEDÍKOVÁ Martina MONFORT Beata RUČILOVÁ Veronika KADLECOVÁ Alena KHIRSARIYA Prashant BARREIRO Zoila Gándara HAVLÍČEK Libor ZATLOUKAL Marek SOURAL Miroslav PARUCH Kamil D'AUTRÉAUX Benoit HAJDÚCH Marián STRNAD Miroslav VOLLER Jiří

  Article in Periodical

  Bioorganic and Medicinal Chemistry, year: 2021, volume: 33, edition: March, DOI

• Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core

  NĚMEC Václav MAIER Lukáš BERGER Benedict-Tilman CHAIKUAD Apirat DRÁPELA Stanislav SOUČEK Karel KNAPP Stefan PARUCH Kamil

  Article in Periodical

  European Journal of Medicinal Chemistry, year: 2021, volume: 215, edition: April, DOI

• CHK1 INHIBITOR SCH900776 ENHANCES ANTICANCER ACTION OF CISPLATIN AND TRAIL VIA STIMULATION OF BAK-DEPENDENT MITOCHONDRIAL PATHWAY

  KRKOŠKA Martin PARUCH Kamil HYRŠLOVÁ VACULOVÁ Alena HERŮDKOVÁ Jarmila

  Conference abstract

  Year: 2021, type: Conference abstract

• SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES

  PARUCH Kamil CARBAIN Benoit Jean-Pierre HAVEL Štěpán DAMBORSKÝ Jiří BREZOVSKÝ Jan DANIEL Lukáš SISÁKOVÁ Alexandra NIKULENKOV Fedor KREJČÍ Lumír

  Patent

  Publisher: European Patent Office, state: Germany, patent's number: EP3556755B1, year: 2021