Ing. RNDr. Martin Marek, Ph.D., MBA

2022

• Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin

  NIKITIN Dmitri MIČAN Jan TOUL Martin BEDNÁŘ David PEŠKOVÁ Michaela KITTOVÁ Patrícia THALEROVÁ Sandra VÍTEČEK Jan DAMBORSKÝ Jiří MIKULÍK Robert FLEISHMAN Sarel J. PROKOP Zbyněk MAREK Martin

  Article in Periodical

  Computational and Structural Biotechnology Journal, year: 2022, volume: 20, edition: May 2022, DOI

• Extended Mechanism of the Plasminogen Activator Staphylokinase Revealed by Global Kinetic Analysis: 1000-fold Higher Catalytic Activity than That of Clinically Used Alteplase

  TOUL Martin NIKITIN Dmitri MAREK Martin DAMBORSKÝ Jiří PROKOP Zbyněk

  Article in Periodical

  ACS Catalysis, year: 2022, volume: 12, edition: 7, DOI

• Hidden Potential of Highly Efficient and Widely Accessible Thrombolytic Staphylokinase

  TOUL Martin MIČAN Jan SLONKOVÁ Veronika NIKITIN Dmitri MAREK Martin BEDNÁŘ David DAMBORSKÝ Jiří PROKOP Zbyněk

  Article in Periodical

  Stroke, year: 2022, volume: 53, edition: 10, DOI

• Increased occurrence of Treponema spp. and double-species infections in patients with Alzheimer's disease

  NEMERGUT Michal BÁŤKOVÁ Tereza VIGAŠOVÁ Dana BARTOŠ Milan HLOZANKOVA Martina SMITH Andrea LIŠKOVÁ Barbora SHEARDOVÁ Kateřina VYHNALEK Martin HORT Jakub LACZO Jan KOVÁČOVÁ Ingrid ŠITINA Michal MATEJ Radoslav JANČÁLEK Radim MAREK Martin DAMBORSKÝ Jiří

  Article in Periodical

  Science of the Total Environment, year: 2022, volume: 844, edition: October 2022, DOI

• Mechanism-Based Strategy for Optimizing HaloTag Protein Labeling

  MARQUES Sérgio Manuel SLÁNSKÁ Michaela CHMELOVÁ Klaudia CHALOUPKOVÁ Radka MAREK Martin CLARK Spencer DAMBORSKÝ Jiří KOOL Eric T. BEDNÁŘ David PROKOP Zbyněk

  Article in Periodical

  JACS AU, year: 2022, volume: 2, edition: 6, DOI

2021

• Computational enzyme design for metabolic engineering

  DAMBORSKÝ Jiří BEDNÁŘ David PROKOP Zbyněk MAREK Martin MAZURENKO Stanislav ŠTOURAČ Jan MARQUES Sérgio Manuel FONSECA PINTO Gabriela Filipa PLANAS IGLESIAS Joan MUSIL Miloš HON Jiří VÁVRA Ondřej KHAN Rayyan Tariq FILIPOVIČ Jiří KOZLÍKOVÁ Barbora

  Conference abstract

  Year: 2021, type: Conference abstract

• Computational Enzyme Stabilization Can Affect Folding Energy Landscapes and Lead to Catalytically Enhanced Domain-Swapped Dimers

  MARKOVÁ Klára KUNKA Antonín CHMELOVÁ Klaudia HAVLÁSEK Martin BABKOVÁ Petra MARQUES Sérgio Manuel VAŠINA Michal PLANAS IGLESIAS Joan CHALOUPKOVÁ Radka BEDNÁŘ David PROKOP Zbyněk DAMBORSKÝ Jiří MAREK Martin

  Article in Periodical

  ACS Catalysis, year: 2021, volume: 11, edition: 21, DOI

• Designované a syntetizované geny kódující nově zkonstruované proteinové katalyzátory (luciferázy) s ověřenými vlastnostmi

  MAREK Martin DAMBORSKÝ Jiří BEDNÁŘ David PLUSKAL Daniel MAJEROVÁ Marika PLANAS IGLESIAS Joan

  Year: 2021

• Engineering protein dynamics for the understanding of divergent evolution of the Renilla luciferase

  TOUL Martin SMITH Andrea RANGEL PAMPLONA PIZARRO PINTO José Gaspar MAREK Martin HERNYCHOVÁ Lenka LIŠKOVÁ Veronika PLUSKAL Daniel EMOND Stephane DÖRR Mark PLANAS IGLESIAS Joan CHALOUPKOVÁ Radka BEDNÁŘ David PROKOP Zbyněk BORNSCHEUER Uwe T. HOLLFELDER Florian DAMBORSKÝ Jiří

  Conference abstract

  Year: 2021, type: Conference abstract

• Engineering the protein dynamics of an ancestral luciferase

  SCHENKMAYEROVÁ Andrea RANGEL PAMPLONA PIZARRO PINTO José Gaspar TOUL Martin MAREK Martin HERNYCHOVÁ Lenka PLANAS IGLESIAS Joan LIŠKOVÁ Veronika PLUSKAL Daniel VAŠINA Michal EMOND Stephane DÖRR Mark CHALOUPKOVÁ Radka BEDNÁŘ David PROKOP Zbyněk HOLLFELDER Florian BORNSCHEUER Uwe T. DAMBORSKÝ Jiří

  Article in Periodical

  Nature Communications, year: 2021, volume: 12, edition: 1, DOI