Ing. RNDr. Martin Marek, Ph.D., MBA

2021

• Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2

  MAREK Martin RAMOS-MORALES E. PICCHI-CONSTANTE G.F.A. BAYER T. NORSTROM C. HERP D. SALES P.A. GUERRA-SLOMPO E.P. HAUSMANN K. CHAKRABARTI A. SHAIK T.B. MERZ A. TROESCH E. SCHMIDTKUNZ K. GOLDENBERG S. PIERCE R.J. MOURAO MM JUNG M.M. SCHULTZ J. SIPPL W. ZANCHIN N.I.T. ROMIER C.

  Article in Periodical

  Cell Reports, year: 2021, volume: 37, edition: 12, DOI

• The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination

  RAMOS-MORALES Elizabeth BAYAM Efil DEL-POZO-RODRIGUEZ Jordi SALINAS-GIEGE Thalia MAREK Martin TILLY Ramos-Morales, E (Ramos- WOLFF Philippe TROESCH Edouard ENNIFAR Eric DROUARD Laurence GODIN Juliette D. ROMIER Christophe

  Article in Periodical

  Nucleic acids research, year: 2021, volume: 49, edition: 11, DOI

2020

• Decoding the intricate network of molecular interactions of a hyperstable engineered biocatalyst

  MARKOVÁ Klára CHMELOVÁ Klaudia MARQUES Sérgio Manuel CARPENTIER Philippe BEDNÁŘ David DAMBORSKÝ Jiří MAREK Martin

  Article in Periodical

  Chemical Science, year: 2020, volume: 11, edition: 41, DOI

• Structural and catalytic effects of surface loop-helix transplantation within haloalkane dehalogenase family

  MAREK Martin CHALOUPKOVÁ Radka PRUDNIKOVA Tanyana SATO Yukari REZACOVA Pavlina NAGATA Yuji SMATANOVA KUTA Ivana DAMBORSKÝ Jiří

  Article in Periodical

  Computational and Structural Biotechnology Journal, year: 2020, volume: 18, edition: December 2020, DOI

• Structures of hyperstable ancestral haloalkane dehalogenases show restricted conformational dynamics

  BABKOVÁ Petra DUNAJOVÁ Zuzana CHALOUPKOVÁ Radka DAMBORSKÝ Jiří BEDNÁŘ David MAREK Martin

  Article in Periodical

  Computational and Structural Biotechnology Journal, year: 2020, volume: 18, edition: 2020, DOI

2019

• Functional switching based on altered enzyme flexibility via InDel mutagenesis of a reconstructed ancestor

  SCHENKMAYEROVA A. PINTO G. MAREK Martin TOUL Martin HERNYCHOVÁ Lenka LIŠKOVÁ Veronika EMOND S. BEDNÁŘ David PROKOP Zbyněk CHALOUPKOVÁ Radka HOLLFELDER F. BORNSCHEUER U.T.

  Conference abstract

  Year: 2019, type: Conference abstract

• Light-Emitting Dehalogenases: Reconstruction of Multifunctional Biocatalysts

  CHALOUPKOVÁ Radka LIŠKOVÁ Veronika TOUL Martin MARKOVÁ Klára ŠEBESTOVÁ Eva HERNYCHOVÁ Lenka MAREK Martin RANGEL PAMPLONA PIZARRO PINTO José Gaspar PLUSKAL Daniel WATERMAN Jitka PROKOP Zbyněk DAMBORSKÝ Jiří

  Article in Periodical

  ACS Catalysis, year: 2019, volume: 9, edition: 6, DOI

• One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity

  ZESSIN M. KUTIL Z. MELESHIN M. NOVAKOVA Z. GHAZY E. KALBAS D. MAREK Martin ROMIER C. SIPPL W. BARINKA C. SCHUTKOWSKI M.

  Article in Periodical

  Biochemistry, year: 2019, volume: 58, edition: 48, DOI

2018

• A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

  SIMOBEN Conrad V. ROBAA Dina CHAKRABARTI Alokta SCHMIDTKUNZ Karin MAREK Martin LANCELOT Julien KANNAN Srinivasaraghavan MELESINA Jelena SHAIK Tajith B. PIERCE Raymond J. ROMIER Christophe JUNG Manfred SIPPL Wolfgang

  Article in Periodical

  Molecules, year: 2018, volume: 23, edition: 3, DOI

• Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants

  MAREK Martin SHAIK Tajith B. HEIMBURG Tino CHAKRABARTI Alokta LANCELOT Julien RAMOS-MORALES Elizabeth DA VEIGA Cyrielle KALININ Dmitrii MELESINA Jelena ROBAA Dina SCHMIDTKUNZ Karin SUZUKI Takayoshi HOLL Ralph ENNIFAR Eric PIERCE Raymond J. JUNG Manfred SIPPL Wolfgang ROMIER Christophe

  Article in Periodical

  Journal of Medicinal Chemistry, year: 2018, volume: 61, edition: 22, DOI