Mgr. Miroslav Vařecha, Ph.D.

2021

• Loss of Sprouty produces a ciliopathic skeletal phenotype in mice through elongation of primary cilia and upregulation of Hedgehog signaling

  HRUBÁ Eva KAVKOVÁ Michaela DALECKÁ Linda MACHOLÁN Miloš ZIKMUND Tomáš VAŘECHA Miroslav BOSÁKOVÁ Michaela KAISER Jozef KREJČÍ Pavel HOVOŘÁKOVÁ Mária BUCHTOVÁ Marcela

  Conference abstract

  Year: 2021, type: Conference abstract

• Loss of Sprouty Produces a Ciliopathic Skeletal Phenotype in Mice Through Upregulation of Hedgehog Signaling

  HRUBÁ Eva KAVKOVÁ Michaela DALECKÁ Linda MACHOLÁN Miloš ZIKMUND Tomáš VAŘECHA Miroslav BOSÁKOVÁ Michaela KAISER Jozef KREJČÍ Pavel HOVOŘÁKOVÁ Mária BUCHTOVÁ Marcela

  Article in Periodical

  Journal of Bone and Mineral Research, year: 2021, volume: 36, edition: 11, DOI

2020

• Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling

  BOSÁKOVÁ Michaela POOVAKULATHU ABRAHAM Sara NITĂ Alexandru HRUBA Eva BUCHTOVA Marcela TAYLOR S. Paige DURAN Ivan MARTIN Jorge SVOZILOVÁ Kateřina BÁRTA Tomáš VAŘECHA Miroslav BÁLEK Lukáš KOHOUTEK Jiri RADASZKIEWICZ Tomasz Witold PUSAPATI Ganesh V. BRYJA Vítězslav RUSH Eric T. THIFFAULT Isabelle NICKERSON Deborah A. BAMSHAD Michael J. ROHATGI Rajat COHN Daniel H. KRAKOW Deborah KREJČÍ Pavel

  Article in Periodical

  EMBO MOLECULAR MEDICINE, year: 2020, volume: 12, edition: 11, DOI

2019

• Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase

  BOSÁKOVÁ Michaela NITĂ Alexandru GREGOR Tomáš VAŘECHA Miroslav GUDERNOVÁ Iva FAFÍLEK Bohumil BÁRTA Tomáš BASHEER Neha POOVAKULATHU ABRAHAM Sara BÁLEK Lukáš TOMANOVÁ Markéta FIALOVÁ KUČEROVÁ Jana BOSÁK Juraj POTĚŠIL David ZIEBA Jennifer SONG Jieun KONIK Peter PARK Sohyun DURAN Ivan ZDRÁHAL Zbyněk ŠMAJS David JANSEN Gert FU Zheng KO Hyuk Wan HAMPL Aleš TRANTÍREK Lukáš KRAKOW Deborah KREJČÍ Pavel

  Article in Periodical

  Proceedings of the National Academy of Sciences of the United States of America, year: 2019, volume: 116, edition: 10, DOI

2018

• Nanodiamonds as "artificial proteins": Regulation of a cell signalling system using low nanomolar solutions of inorganic nanocrystals

  BÁLEK Lukáš BUCHTOVÁ Marcela BOSÁKOVÁ Michaela VAŘECHA Miroslav TRANTÍRKOVÁ Silvie GUDERNOVÁ Iva VESELÁ Iva HAVLIK Jan NEBURKOVA Jitka TURNER Stuart KRZYSCIK Mateusz Adam ZAKRZEWSKA Malgorzata KLIMASCHEWSKI Lars CLAUS Peter TRANTÍREK Lukáš CIGLER Petr KREJČÍ Pavel

  Article in Periodical

  Biomaterials, year: 2018, volume: 176, edition: SEP 2018, DOI

• Proteomic analyses of signalling complexes associated with receptor tyrosine kinase identify novel members of fibroblast growth factor receptor 3 interactome

  BÁLEK Lukáš NĚMEC Pavel KONIK P. BOSÁKOVÁ Michaela VAŘECHA Miroslav GUDERNOVÁ Iva MEDALOVÁ Jiřina KRAKOW Deborah KREJČÍ Pavel

  Article in Periodical

  Cellular Signalling, year: 2018, volume: 42, edition: JAN 2018, DOI

• Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies

  BOSÁKOVÁ Michaela VAŘECHA Miroslav HAMPL Marek DURAN Ivan NITĂ Alexandru BUCHTOVÁ Marcela DOSEDELOVA Hana MACHÁT Radek XIE Yangli NI Zhenhong MARTIN Jorge H. CHEN Lin JANSEN Gert KRAKOW Deborah KREJČÍ Pavel

  Article in Periodical

  Human molecular genetics, year: 2018, volume: 27, edition: 6, DOI

• The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases

  FAFÍLEK Bohumil BÁLEK Lukáš BOSÁKOVÁ Michaela VAŘECHA Miroslav NITĂ Alexandru GREGOR Tomáš GUDERNOVÁ Iva KŘENOVÁ Jitka GHOSH S. PISKÁČEK Martin JONATOVA Lucie ČERNOHORSKÁ Nicole ZIEBA J.T. KOSTAS M. HAUGSTEN E.M. WESCHE J. ERNEUX C. TRANTÍREK Lukáš KRAKOW D. KREJČÍ Pavel

  Article in Periodical

  SCIENCE SIGNALING, year: 2018, volume: 11, edition: 548, DOI

2017

• ARQ 087 inhibits FGFR signaling and rescues aberrant cell proliferation and differentiation in experimental models of craniosynostoses and chondrodysplasias caused by activating mutations in FGFR1, FGFR2 and FGFR3

  BÁLEK Lukáš GUDERNOVÁ Iva VESELA Iva HAMPL Marek ORALOVÁ Veronika BOSÁKOVÁ Michaela VAŘECHA Miroslav NĚMEC Pavel HALL Terence ABBADESSA Giovanni HATCH Nan BUCHTOVÁ marcela KREJČÍ Pavel

  Article in Periodical

  Bone, year: 2017, volume: 105, edition: DEC 2017, DOI

• Differences in anterior-posterior sensitivity of early limb bud cell to FGF/WNT treatment

  KILLINGER Michael HRUBÁ Eva VAŘECHA Miroslav KREJČÍ Pavel BUCHTOVÁ marcela

  Conference abstract

  Year: 2017, type: Conference abstract