Mgr. Miroslav Vařecha, Ph.D.

2017

• Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480

  GUDERNOVÁ Iva BÁLEK Lukáš VAŘECHA Miroslav FIALOVÁ KUČEROVÁ Jana BOSÁKOVÁ Michaela FAFÍLEK Bohumil PALUŠOVÁ Veronika ULDRIJAN Stjepan TRANTÍREK Lukáš KREJČÍ Pavel

  Article in Periodical

  Oncotarget, year: 2017, volume: 8, edition: 65, DOI

• One reporter for in-cell activity profiling of majority of protein kinase oncogenes

  GUDERNOVÁ Iva TRANTÍRKOVÁ Silvie EL GHANNAMOVÁ Barbora FAFÍLEK Bohumil VAŘECHA Miroslav BÁLEK Lukáš HRUBÁ Eva JONÁTOVÁ Lucie JELÍNKOVÁ Iva BOSÁKOVÁ Michaela TRANTÍREK Lukáš MAYER Jiří KREJČÍ Pavel

  Article in Periodical

  eLife, year: 2017, volume: 6, edition: "e21536", DOI

• Statins do not inhibit the FGFR signaling in chondrocytes

  FAFÍLEK Bohumil HAMPL Marek ŘIČÁNKOVÁ Nikola VESELA I. BÁLEK Lukáš BOSÁKOVÁ Michaela GUDERNOVÁ Iva VAŘECHA Miroslav BUCHTOVÁ marcela KREJČÍ Pavel

  Article in Periodical

  Osteoarthritis and Cartilage, year: 2017, volume: 25, edition: 9, DOI

• Tyrosine Kinase Expressed in Hepatocellular Carcinoma, TEC, Controls Pluripotency and Early Cell Fate Decisions of Human Pluripotent Stem Cells via Regulation of Fibroblast Growth Factor-2 Secretion

  VÁŇOVÁ Tereza KONEČNÁ Žaneta ZBOŇÁKOVÁ Zuzana LA VENUTA Giuseppe ZOUFALOVÁ Karolína JELÍNKOVÁ Šárka VAŘECHA Miroslav ROTREKL Vladimír KREJČÍ Pavel NICKEL Walter DVOŘÁK Petr BOSÁKOVÁ Michaela

  Article in Periodical

  Stem Cells, year: 2017, volume: 35, edition: 9, DOI

2016

• An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome

  TAYLOR S. Paige BOSÁKOVÁ Michaela VAŘECHA Miroslav BÁLEK Lukáš BÁRTA Tomáš TRANTÍREK Lukáš JELÍNKOVÁ Iva DURAN Ivan VESELÁ Iva FORLENZA Kimberly N. MARTIN Jorge H. HAMPL Aleš BAMSHAD Michael NICKERSON Deborah JAWORSKI Margie L. SONG Jieun WAN KO Hyuk COHN Daniel H. KRAKOW Deborah KREJČÍ Pavel

  Article in Periodical

  Human Molecular Genetics, year: 2016, volume: 25, edition: 18, DOI

• HUMAN EMBRYONIC STEM CELL-BASED NEURAL DEVELOPMENTAL MODELING REVEALS THE VERSATILE ROLES OF FGF2 SIGNALING

  GRABIEC Marta HŘÍBKOVÁ Hana VAŘECHA Miroslav DVOŘÁK Petr WADELEY Yuh-Man

  Conference abstract

  Year: 2016, type: Conference abstract

• Stage-specific roles of FGF2 signaling in human neural development

  GRABIEC Marta HŘÍBKOVÁ Hana VAŘECHA Miroslav STŘÍTECKÁ Dana HAMPL Aleš DVOŘÁK Petr SUN Yuh-Man

  Article in Periodical

  Stem Cell Research, year: 2016, volume: 17, edition: 2, DOI

2015

• Fibroblast growth factor and canonical WNT/beta-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage

  BUCHTOVÁ marcela ORALOVÁ Veronika AKLIAN Anie MAŠEK Jan VESELA Iva OUYANG Zhufeng OBADALOVÁ Tereza KONEČNÁ Žaneta SPOUSTOVÁ Tereza POSPÍŠILOVÁ Tereza MATULA Petr VAŘECHA Miroslav BÁLEK Lukáš GUDERNOVÁ Iva JELÍNKOVÁ Iva DURAN Ivan ČERVENKOVÁ Iveta MURAKAMI Shunichi KOZUBÍK Alois DVOŘÁK Petr BRYJA Vítězslav KREJČÍ Pavel

  Article in Periodical

  Biochimica et Biophysica Acta - Molecular Basis of Disease, year: 2015, volume: 1852, edition: 5, DOI

2012

• Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis

  VAŘECHA Miroslav POTĚŠILOVÁ Michaela MATULA Pavel KOZUBEK Michal

  Article in Periodical

  Mol Cell Biochem, year: 2012, volume: 363, edition: 1-2, DOI

• Knockdown of apoptosis-inducing factor disrupts function of respiratory complex I

  VAŘECHA Miroslav PÁCLOVÁ Daniela PROCHÁZKOVÁ Jiřina MATULA Pavel CMARKO Dušan KOZUBEK Michal

  Article in Periodical

  BIOCELL, year: 2012, volume: 36, edition: 3