Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1208
2011
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Characterization of PVL-phages induced from community-acquired Staphylococcus aureus strains
Year: 2011, type: Conference abstract
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CHARACTERIZATION OF THE NSE4/EID BINDING TO NSE3/MAGE PROTEINS
Year: 2011, type: Conference abstract
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Charakterizácia kmeňov Escherichia coli izolovaných od osôb s ochoreniami tráviaceho traktu.
Year: 2011, type: Conference abstract
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Chimeric CYP21A1P/CYP21A2 genes identified in Czech patients with congenital adrenal hyperplasia
European Journal of Medical Genetics, year: 2011, volume: 54, edition: 2, DOI
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Chromosomal abnormalities in monoclonal gammopathy of undetermined significance patients analyzed by fluorescence in situ hybridization and oligonucleotide based array comparative genomic hybridization
Year: 2011, type: Conference abstract
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Chromosomal analysis of anaplastic ependymoma and diffuse astrocytoma presenting as synchronous primary brain tumors in a child (case report)
Year: 2011, type: Conference abstract
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Identification of Bifidobacterium spp. isolated from children intestinal mucous tissue samples by MALDI-TOF MS and automated ribotyping
Year: 2011, type: Conference abstract
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Identification of cells with cancer stem cell phenotype in rhabdomyosarcoma.
Year: 2011, type: Conference abstract
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Identification of Lactobacillus spp. isolates from children's intestinal tissues by MALDI-TOF MS profiling and automated ribotyping
Year: 2011, type: Conference abstract
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Identification of syphilis susceptibility locus - a pilot study
Year: 2011, type: Conference abstract