Project information
Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
- Project Identification
- MSM0021622430
- Project Period
- 1/2007 - 12/2013
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Other MU Faculty/Unit
- Faculty of Informatics
- Other MU Faculty/Unit
- Central European Institute of Technology
- Keywords
- embryonic stem cells
The goal of this project will be a) to profit from availability of unique cellular resources - mouse and human embryonic stem cells and normal and malignant hematopoietic stem/progenitor cells, b) to effectively employ a wide variety of current and complementary methodologies available to the consortium, and c) to exploit a proven/certified expertise in working with various living systems that span from in vitro cultured cells, through animal models to oncohematological patients. All this together will represent a powerful experimental platform aimed at addressing a nature of molecules and molecular mechanisms underlaying phenomena that are common to both normal and cancer stem cells, mainly their ability to self-renew and to enter differentiation pathways. Integral part of this general goal is to implement multifaceted analytical approach that will cover studies of gene expression at both mRNA and protein levels, evaluating function of extra and intracellular signaling pathways, and analyzing biological properties of cells in vitro and in vivo. Expected outcome will be not only understanding but also a definition of molecules and/or molecular pathways to be tested as therapeutic targets, and cellular models that will make such testing feasible.
Publications
Total number of publications: 357
2011
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Stimulation of cell adhesion and proliferation by "Click&Seed" system
Year: 2011, type: Conference abstract
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Stromální buňky chrání maligní B-lymfocyty před rituximabem indukovanou apoptózou a inhibice integrinu alfa-4-beta-1 (VLA-4) umožňuje překonat tuto rezistenci
Year: 2011, type: Conference abstract
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Structural and Functional Characterization of the Wnt Inhibitor APC Membrane Recruitment 1 (Amer1)
JOURNAL OF BIOLOGICAL CHEMISTRY, year: 2011, volume: 286, edition: 22, DOI
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TGF-beta 1-Induced EMT of Non-Transformed Prostate Hyperplasia Cells Is Characterized by Early Induction of SNAI2/Slug
Prostate, year: 2011, volume: 71, edition: 12, DOI
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The impact of specific mutations in TP53 gene on the results of alemtuzumab therapy in chronic lymphocytic leukemia patients
Year: 2011, type: Conference abstract
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The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhR-dependent transcription and Wnt/beta catenin signaling in liver progenitors.
Toxicological sciences, year: 2011, volume: 122, edition: 2, DOI
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The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34+ CML stem/progenitor cells
Leukemia, year: 2011, volume: 25, edition: 7, DOI
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The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting insuppression of human myeloma cell growth and survival.
Leukemia, year: 2011, volume: 25, edition: 3, DOI
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The predictive value of human organic cation transporter 1 and ABCB1 expression levels in different cell populations of patients with de novo chronic myelogenous leukemia
International Journal of Hematology, year: 2011, volume: 94, edition: 3, DOI
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The regulation, targets, and clinical relevance of microRNA mir-650 in chronic lymphocytic leukemia (CLL)
Year: 2011, type: Conference abstract