Project information
Molecular pathophysiology of multigene diseases
- Project Identification
- MSM 141100002
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- Multigenic disease, essential hypertension, ischemia, atopy, diabetes type II, late complications of diabetes, matrix metalloproteinase, gene polymorphism, remodeling, gene derepression, case-control study, PCR, SSCP, RFLP, sequencing.
Effects of allelic variability of the genes coding for matrix metalloproteinases (MMPs) on the etiopathogenesis of the essential hypertension, myocardial ischemia, atopic diseases, and late complications of diabetes II will be studied. Genotyping of individuals will be performed using molecular biological methods, especially PCR, SSCP, RFLP, and/or direct sequencing. Groups of diseased persons will be compared with the appropriate control groups (case-control study).
Publications
Total number of publications: 232
2004
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Nový častý polymorfismu 17654 C/T v genu pro trankripční represorový onkoprotein Gfi-1 u kožních T-lymfomů
Sborník XXI. Sjezdu českých a slovenských alergologů a klinických imunologů, Brno, 2004, supp 2, year: 2004
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Patogenetická role přetížení železem u jaterních onemocnění
XXXII. Májové hepatologické dny, year: 2004
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Peroxisome Proliferator-Activated Receptors Gene Polymorphisms in Chronic Heart Failure And Triple-Vessel Disease
Year: 2004, type: Conference abstract
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The inducible nitric oxide synthase (NOS2) gene promoter polymorphisms and allergic disorders in the Central European population
European Respiratory Journal, year: 2004
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Transcription repressor autoregulation: Mathematical/ numerical analysis of delay negative feedback system
5th ICSB International Conference on Systems Biology, year: 2004
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Two Introne RXR Alpha Polymorphisms in Chronic Heart Failure
Year: 2004, type: Conference abstract
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Two TNF polymorphisms in rheumatoid arthritis
Year: 2004, type: Conference abstract
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Úloha polymorfizmů v promotoru genu pro receptor CD14 u atopických nemocí v české populaci
Alergie, year: 2004, volume: 6, edition: Suppl.2
2003
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3` TACE GENE POLYMORPHISM IS RELATED TO DILATED CARDIOMYOPATHY, CARDIOTHORACIC INDEX AND PULMONARY CONGESTION IN CHRONIC HEART FAILURE
Year: 2003, type: Conference abstract
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A gender-specific association between a novel A5495G variant in the endothelial nitrix oxide synthase gene (NOS3) and respiratory allergy in the Czech population
Eur.Respir.J., year: 2003, volume: 22, edition: Suppl 45