Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2003
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Development of an analytical method for PAH and their derivatives analysis. A utilising of a pressurised solvent extraction and extract clean-up.
27th Symposium on high performance liquid phase separations and related techniques., year: 2003
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Dioxin as unwanted product in manufacturing 2,4,5-T herbicides in Czechia: Health and environmental problems
International Ecological Forum, year: 2003
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Emergent threats to the Chemical Weapons Convention
19th Workshop of the Pugwash Study Group on the Implementation of the Chemical and Biological Weapons Conventions: The First CWC Review Conference and Beyond, year: 2003
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Environmental threats posed by sea-dumped and earth-buried chemicalweapons in the Central European and Baltic Regions
6th International Symposium on Environmental Contamination in Central and Eastern Europe and the Commonwealth of Independent States, year: 2003
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Evaluation of the importance of bronchoscopy in the intensive care units
European Respiratory Journal, year: 2003, volume: 22, edition: sup 45
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Faktory ovlivňující přežití nemocných s nediseminovaným nemalobuněčným bronchogenním karcinomem
Edukační sborník, year: 2003
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Forms and material sources of CBRN-Terrorism.
Symposium on nuclear, biological and chemical threats A crisis management challenge, NBC 2003,Jyväskylä 2003, University of Jyväskylä Research Report No 98, year: 2003
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Gemcitabine plus cisplain vs. gecitabine plus carboplatin in stage IIIb and IV non small cell lung cancer: A phase III randomized trial
Lung Cancer, year: 2003, volume: 41, edition: 3
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Gemcitabine plus Cisplatin versus Gemcitabine plus Carboplatin in Stage IIIb and IV Non Small Lung Cancer: A phase III Randomized Trial
Lung Cancer, year: 2003, volume: 41, edition: sup 2
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Generation of antigen-loaded dendritic cells in a serum-free medium using different cytokine combinations.
Vaccine, year: 2003, volume: neuveden, edition: 2/2003