Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2003
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New threats of terrorism: Chemical, biological, radiological and nuclear terrorism (State project)
International Symposium Medical and Biological Aspects of Chemical Weapons Stockpile Demilitarization, year: 2003
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New trends in the development of means for skin protection
Symposium on nuclear, biological and chemical threats A crisis management challenge, NBC 2003, year: 2003
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Nové směry vývoje protinádorové léčby
Obecná onkologie a podpůrná léčba. Eds. Adam Z., Vorlíček J., Koptíková J., year: 2003, number of pages: 21 s.
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Novel approach to monitoring of the soil biological quality
Environment International, year: 2003, volume: 28, edition: 8
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Obecná epidemiologie nádorů hlavy a krku
Onkologická péče, year: 2003, volume: 7, edition: 2
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Ochrana obyvatelstva v proměnách času IX. Transformace civilní obrany na civilní ochranu
Rescue Report, year: 2003, volume: 6, edition: 3
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Ochrana obyvatelstva v proměnách času VII. Poválečná civilní obrana vevyspělých neutrálních zemích
Rescue Report, year: 2003, volume: 6, edition: 1
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Ochrana obyvatelstva v proměnách času VIII. Vliv mírových hrozeb na organizaci ochrany obyvatelstva
Rescue Report, year: 2003, volume: 6, edition: 2
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Ochrana obyvatelstva v proměnách času X.Růst mírových hrozeb a československá civilní obrana.
Rescue Report, year: 2003, volume: 6, edition: 4
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Ochrana obyvatelstva v proměnách času XI Ochrana obyvatelstva v Československu v 80. letech
Rescue Report, year: 2003, volume: 6, edition: 5