Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2002
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Inhibition of gap junctional intercellular communication and the activation of mitogen activated protein kinase by PCBs depends on substitution of chlorine ortho-position
The Second PCB Workshop. Recent Advances in the Environmental Toxicology and Health Effects of PCBs. Book of Abstracts, year: 2002
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Inhibition of gap-junctional intercellular communication by environmentally occuring polycyclic aromatic hydrocarbons
Toxicological Sciences, year: 2002, volume: 65, edition: 1
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Interleukin-2 Activation of Haematopoietic Stem Cells
Acta Medica Austriaca, year: 2002, volume: 2002, edition: 2
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Isomer-specific analysis of PCN and dioxin-like compounds in DELORs, technical PCB mixtures from former Czechoslovakia
Book of Abstracts - The 2nd PCB Workshop: Recent Advances in the Environmental Toxicology and Health Effects of PCBs Emphasis on the latest advances and the perspective of Central and Eastern Europe. Brno, CR, 07-11/05/2002, year: 2002
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Karotická endarterectomie - angioskopie
VI. slovenský kongres cievnej chirurgie, year: 2002
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Kořeny a rané tradice vysokoškolské výuky chemie v Brně
54. sjezd chemických společností, year: 2002
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Malignant melanoma associates with Th1/Th2 imbalance that coincides with disease progression and immunotherapy response
Neoplasma, year: 2002, volume: 3, edition: 49
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Mathematical model predicting individual breast cancer risk. The result of case-control study of 7,000 women
INTERNATIONAL JOURNAL OF CANCER, year: 2002, volume: 13, edition: 1
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Mezinárodně-právní aspekty boje proti globálnímu terorismu
Mezinárodní politika, year: 2002, volume: 26, edition: 8
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Mezinárodně-právní aspekty boje proti terorismu.
VI. Mezinárodní konference Medicina katastrof, Zlín-Lukov 2002, Sborník přednášek, year: 2002