Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2002
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New generations of protective masks for armed forces and civil protection
NATO-RTA-SAS Panel Symposium on Defensive Aspects of Chemical and Biological Warfare , Delft 2002. Abstracts, year: 2002
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New generations of protective means for rescue operations following terrorist chemical, biological and radiological attacks.
2002 Joint Service Scientific Conference on Chemical & Biological Defense Research, Baltimore Hunt Valley 2002.Abstract Digest, year: 2002
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New threats for the 21st century: Chemical, biological, radiological and nuclear terrorism
INES Seminář: New Security Global and Regional Priorities, year: 2002
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New threats of terrorism for the 21st century: CBRN Terrorism
EuPRA Conference: Europe as a Peaceful Power ?, year: 2002
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New threats of terrorism for the 21st century: Chemical, biological, radiological and nuclear terrorism
The 4th International Chemical and Biological Medical Treatment Symposium, Spiez 2002. Abstract of Presentations, year: 2002
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New trends in skin protection for armed forces and civil protection
NATO-RTA-SAS Panel Symposium on Defensive Aspects of Chemical and Biological Warfare, year: 2002
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Non-genotoxic effects of hydroxy-PCBs and PCB-quinones in liver and mammary in vitro models
Book of Abstracts - The 2nd PCB Workshop: Recent Advances in the Environmental Toxicology and Health Effects of PCBs Emphasis on the latest advances and the perspective of Central and Eastern Europe. Brno, CR, 07-11/05/2002, year: 2002
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Nongenotoxic modes of action of polycyclic aromatic hydrocarbons and their relative potencies in rat liver cellular models. Ecotoxicological significance of individual compounds in abiotic samples
Book of Abstracts - SECOTOX 2002, Trends and Advances in Environmental Chemistry and Ecotoxicology, Brno, 14-16/10/2002, year: 2002
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Obraz pneumocystové pneumonie v roce 2001
Sborník souhrnů přednášek - XI. Tomáškovy dny 2002, year: 2002
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Ochrana obyvatelstva v proměnách času I. Přírodní a válečné hrozby v historii preludium civilní obrany
Rescue Report, year: 2002, volume: 5, edition: 1