Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2002
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Toxicological and radiotoxicological problems of using anti-armour munitions containing depleted uranium
54. Sjezd chemických společností, year: 2002
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Toxicological and radiotoxicological problems of using anti-armour munitions containing depleted uranium core
2nd Meeting on Chemistry and Life, year: 2002
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Ultraterorismus - jaderný, radiologický, chemický a biologický terorismus
Vojenské rozhledy : teoretický časopis armády České republiky, year: 2002, volume: 43, edition: 1
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Use of bronchoalveolar lavage (BAL) in diagnosis and treatment of pulmonary complications in immunocompromised patients in intensieve care unit (ICU)
European Respiratory Journal, year: 2002
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Using microbial summary parameters as biological indicators of soil quality in long term cultivation of real soils
Book of Abstracts - SECOTOX 2002, Trends and Advances in Environmental Chemistry and Ecotoxicology, Brno, 14-16/10/2002, year: 2002
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Vícerozměrné hodnocení biologické kvality půd: validace bioindikačních a diskriminačních schopností
Sborník pracovní konference - Ekotoxikologické Biotesty I, Seč u Chrudimi, 18-19/9/2002, year: 2002
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Vliv nově syntetizovaných chalkonù na epigenetické faktory karcinogeneze
Chemické Listy, year: 2002, volume: 96, edition: 6
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Vliv nově syntetizovaných chalkonů na epigenetické faktory karcinogeneze
Chemické listy, year: 2002, volume: 96, edition: 6
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Využití dat NOR pro kontrolu kvality onkologické péče - studie vybraných skupin nádorů podpořená software SVOD
Sborník - XXVI. Brněnské onkologické dny, Brno 29.5. - 31.5. 2002, year: 2002
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Využití luminiscenčních in vitro testů pro detekci genotoxického potenciálu
Sborník pracovní konference - Ekotoxikologické Biotesty I, Seč u Chrudimi, 18-19/9/2002, year: 2002