Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2002
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The importance of determination of nucleotide polymorphism in the matrix metalloproteinase-1 (MMP) for the appearence of metastases of lung tumour
Lung Cancer, year: 2002, volume: 37, edition: suppl. 1
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The influence of co-morbidity on the outcome of non-invasive ventialtory supprot in patients with acute respiratory failure (ARF) in chronic abstructive pulmonary disease (COPD)
European Respiratory Journal, year: 2002, volume: 20, edition: 38
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The influence of co-morbidity on the outcome of non-invasive ventilatory support in patients with acute respiratory failure (ARF) in chronic obstructive pulmonary disease (COPD)
European Respiratory Journal, year: 2002
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The influence of co-morbidity on the outcome of non-invasive ventilatory support in patients with acute respiratory failure (ARF) in chronic obstructive pulmonary disease (COPD)
1st Central European Congress on Intensive Care Medicine, year: 2002
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The influence of co-morbidity on the outcome of non-invasive ventilatory support in patients with acute respiratory failure in chronic obstructive pulmonary disease
Biomedical Papers, year: 2002, volume: 146, edition: 1
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The use of bronchoalveolar lavage in diagnosis of pulmonary complications in immunocompromised HIV negative patients
Program - Abstracts, year: 2002
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The Use of Bronchoalveolar Lavage in Diagnosis of Pulmonary Complications in Immunocompromised HIV Negative Patients In: J.F. Beamis, jr., S.M.Shapshay
Proceedings of the 12th World Congress for Bronchology, year: 2002, number of pages: 4 s.
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Threats posed to the Chemical Wepons Convention by the new toxic chemicals and the importance of implementing the CWCs General Purpose Criterion
NATO-ARW: Maximizing the Security Benefits from the First Review Conference of the Chemical Weapons Convention, year: 2002
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Toxaphene congeners levels in various matrices from the Czech environment
Conference SECOTOX East 2002, 7th Regional Meeting of the Central and Eastern European Section, Trends and Advances In Environmental Chemistry and Ecotoxicology, Book of Abstracts appendix, year: 2002
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Toxicological and radiotoxicological problems of using anti-armour munitions containing depleted uranium
Chemické listy, year: 2002, volume: 96, edition: 96