Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2001
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Cyanobakterie jako producenti biologicky aktivních látek a jejich vliv na zdraví obyvatel
SOVAK, year: 2001, volume: 10, edition: 5
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Determination and multivariate statistical analysis of biochemical responses to environmental contaminants in feral freshwater fish Leuciscus cephalus
Environmental Toxicology and Chemistry, year: 2001, volume: 20, edition: 5
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Development of means for the decontamination of supertoxic lethal chemical warfare agents on human skin
The 6th Czech and Slovak International Toxicological Conference, year: 2001
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Development of means for the decontamination of supertoxic lethal chemical warfare agents on human skin.
Voj. zdrav. listy, year: 2001, volume: 70, edition: 1
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Development of solutions and mixtures for the decontamination of supertoxic lethal chemicals on the surfaces of military equipment
7th International Symposium on Protection against Chemical and Biological Warfare Agents, year: 2001
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Die Aktivitäten laut dem Artikel X der Chemiewaffenkonvention
Seminar Verbot der Weiterverbreitung von C-Waffen, year: 2001
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Dissolved microcystins in raw and treated drinking water in the Czech Republic
Cyanotoxins - Occurence, Causes, Consequences, year: 2001, number of pages: 5 s.
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Distribution of polcyclic aromatic hydrocarbons among different compartments of river system
Toxicological and Environmental Chemistry, year: 2001, volume: 80, edition: 1
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Ekotoxikologické biotesty v systému identifikace rizik pro životní prostředí
Sborník konference Ekoanalytika, year: 2001
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EMEP Superstanice - koncepční přístupy
OVZDUŠÍ 2001 - Program a sborník konference, year: 2001