Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2018127
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
-
Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
- Cooperating Organization
-
Institute of Biotechnology CAS
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 327
2022
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Quantitative Acetylomics Uncover Acetylation-Mediated Pathway Changes Following Histone Deacetylase Inhibition in Anaplastic Large Cell Lymphoma
CELLS, year: 2022, volume: 11, edition: 15, DOI
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Reduced graphene oxide/ZnO nanocomposite modified electrode for the detection of tetracycline
Journal of materials science, year: 2022, volume: 57, edition: 9, DOI
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Role of Nse1 Subunit of SMC5/6 Complex as a Ubiquitin Ligase
Cells, year: 2022, volume: 11, edition: 1, DOI
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Seeing the invisible – Study of transiently formed protein conformation found in domain 1.1 of bacterial transcription factor
Year: 2022, type: Appeared in Conference without Proceedings
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Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy
Angewandte Chemie International Edition, year: 2022, volume: 61, edition: 48, DOI
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Short Synthesis of (+)-Actinobolin: Simple Entry to Complex Small-Molecule Inhibitors of Protein Synthesis
Angewandte Chemie International Edition, year: 2022, volume: 61, edition: 17, DOI
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Single Molecules Imaging under SemiPhysiological conditions
Year: 2022, type: Workshop
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Specific phosphorylation of microtubule-associated protein 2c by extracellular signal–regulated kinase reduces interactions at its Pro-rich regions
JOURNAL OF BIOLOGICAL CHEMISTRY, year: 2022, volume: 298, edition: 10, DOI
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Spruce versus Arabidopsis: different strategies of photosynthetic acclimation to light intensity change
Photosynthesis Research, year: 2022, volume: 154, edition: 1, DOI
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Structural analysis of pyrene-labelled G-quadruplexes derived from the KIT proto-oncogene
Year: 2022, type: Conference abstract