Publication details

Small nucleolar RNAs functioning and potential roles in cancer

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Authors

THORENOOR Nithyananda SLABÝ Ondřej

Year of publication 2015
Type Article in Periodical
Magazine / Source Tumor Biology
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://link.springer.com/article/10.1007%2Fs13277-014-2818-8
Doi http://dx.doi.org/10.1007/s13277-014-2818-8
Field Oncology and hematology
Keywords cancer; small nucleolar RNAs; non-coding RNAs; GAS5
Description Non-coding RNAs (ncRNAs) are important regu- latory molecules involved in various physiological and path- ological cellular processes. Small nucleolar RNAs (snoRNAs), subclass of small ncRNAs, have been considered important but unglamorous elements in the production of protein synthesis machinery of cells. However, recent evi- dence has indicated that these non-coding RNAs might have a crucial role also in controlling cell behavior, and snoRNAs dysfunction could significantly contribute to carcinogenesis. Here, we summarize the most important aspects of snoRNAs biology, their functioning in cancer cell, and potential usage in diagnosis or as a new class of therapeutic targets in cancer.
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