Publication details

The C766T low-density lipoprotein receptor related protein polymorphism and coronary artery disease, plasma lipoproteins, and longevity in the Czech population

Authors

BENEŠ Petr MUŽÍK Jan BENEDÍK Jaroslav ELBL Lubomír VAŠKŮ Anna ŠIŠKOVÁ Lenka ZNOJIL Vladimír VÁCHA Jiří

Year of publication 2001
Type Article in Periodical
Magazine / Source Journal of Molecular Medicine
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords Low density lipoprotein receptor related protein; Plasminogen activator inhibitor 1; Coronary artery disease; Genetic polymorphism; Longevity; Plasma lipoproteins
Description Our results demonstrate that the T allele of the C766T LRP polymorphism is negatively related to longevity, and that it increases the risk of CAD development in subjects with the 5G/5G PAI-1 genotype. No significant association was observed between the LRP or PAI-1 polymorphisms and plasma lipoprotein levels in the CAD patients.
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