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The C766T low-density lipoprotein receptor related protein polymorphism and coronary artery disease, plasma lipoproteins, and longevity in the Czech population
Autoři | |
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Rok publikování | 2001 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Journal of Molecular Medicine |
Fakulta / Pracoviště MU | |
Citace | |
Obor | Genetika a molekulární biologie |
Klíčová slova | Low density lipoprotein receptor related protein; Plasminogen activator inhibitor 1; Coronary artery disease; Genetic polymorphism; Longevity; Plasma lipoproteins |
Popis | Our results demonstrate that the T allele of the C766T LRP polymorphism is negatively related to longevity, and that it increases the risk of CAD development in subjects with the 5G/5G PAI-1 genotype. No significant association was observed between the LRP or PAI-1 polymorphisms and plasma lipoprotein levels in the CAD patients. |
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