Publication details
Cytoskeleton in human pathogenic yeasts Cryptococcus neoformans and Aureobasidium pullulans and the effect of cytoskeletal inhibitors.
| Authors | |
|---|---|
| Year of publication | 2001 |
| Type | Article in Periodical |
| Magazine / Source | YEAST |
| MU Faculty or unit | |
| Citation | |
| Field | Other medical specializations |
| Keywords | cytoskeleton; actin; microtubules; yeast human pathogens; cytoskeleton inhibitors |
| Description | The objectives were to identify cytoskeleton and to use cytoskeletal inhibitors to arrest proliferation and induce pathogens death. C. neoformans had actin and microtubules. A. pullulans had multinuclear hyphae. Cytoplasmic microtubules disappeared before spindle formation and synchronous mitoses. Actin cables were absent, but rings and patches occurred. The polymorphy may reflect deficient actin cytoskeleton. Cytochalasin D had no effect on actin structures and proliferation of pathogens. Methylbenzimidazol-2-yl carbamate disintegrated microtubules, blocked mitoses and proliferation. As none of the drugs caused irreversible inhibition of proliferation, further cytoskeletal inhibitors will be investigated. Financial support was provided by Japanese Ministry of Education, Science and Culture for Marie Kopecká as a Guest Professor at Chiba University, Japan in 1998-1999. This project was supported by grant no. 310/00/0391 from the Grant Agency of the Czech Republic. |
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