Publication details

Role of genetic variability in systems of receptor-mediated and enzymatic defence against glycation in long-term consequences of diabetes mellitus

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Authors

KAŇKOVÁ Kateřina

Year of publication 2003
Type Article in Periodical
Magazine / Source Biochemical Society Transactions
MU Faculty or unit

Faculty of Medicine

Citation
Field Endocrinology, diabetology, metabolism, nutrition
Keywords diabetes mellitus; complications; polymorphism; glycation; AGE; methylglyoxal
Description Diabetes mellitus is the most common metabolic disease with late complications due to chronic hyperglycaemia. Altered carbohydrate and lipid metabolism together with impaired detoxification of carbonyl substrates and impaired trapping of oxygen radicals are responsible for diabetic cell damage. Variable functional capacity of detoxifying systems could contribute to different susceptibility to develop complications. Identification of genetic variants responsible for modulating relevant intermediate phenotype in diabetic milieu could help to define individual risk-profile and to modify therapeutic strategy accordingly.
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