Informace o projektu
Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob
- Kód projektu
- VS96097
- Období řešení
- 7/1996 - 12/2000
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Posílení výzkumu na vysokých školách
- Fakulta / Pracoviště MU
- Lékařská fakulta
An extensive study is realized in the framework of the VS 96 097 grant on the expected association between the allelic variants of selected candidate genes with several multigenic common diseases, possibly with their intermediate phenotypes.A "case-control" study research strategy is based on population studies of the genetic polymorphisms of selected candidate genes and the search of the temptative associations of the allelic frequencies with some common "civilization" diseases,as essential hypertension, diabetes mellitus (late complications thereof), atopic diseases and with the propensity of malignant tumors to form metastases. The associations are tested by means of multivariational statistical methods.It can be expected that discovering of genetically profiled subsets of patients will enable to achieve more focused prevention and treatment of the disease studied.
Publikace
Počet publikací: 74
1999
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The best model of a cat is a cat, especially the same cat
Exp Hematol, rok: 1999, ročník: 27, vydání: 1
1998
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Angiotensin I-converting enzyme (ACE) gene and tumor necrosis factor beta (TNF beta) gene polymorphisms in coronary artery disease. A case control study
Scripta Medica, rok: 1998, ročník: 71, vydání: 6-7
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Angiotensin I-converting enzyme and angiotensinogen gene interaction and prediction of essential hypertension
Kidney International, rok: 1998, ročník: 53, vydání: 6
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Angiotensin-converting enzyme gene polymorphism and blood groups of the AB0 system in leukemias compared with controls and hypertensives
Scripta medica, rok: 1998, ročník: 71, vydání: 8
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Association of deletion polymorphism I/D ACE (angiotensin-converting enzyme) gene with asthma bronchiale
In 13th congress Pathological and Clinical Physiology. Abstracts, rok: 1998
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Bronchitis VI (Link between asthma and COPD)
Imunologický zpravodaj, rok: 1998, ročník: XIII, vydání: 3
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Comparison of various methods of population forming using type a behaviour pattern (TABP) score related genotype
Behav. Pharmacol., rok: 1998, ročník: 9, vydání: Suppl. 1
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Does angiotensin I-converting enzyme inhibitor therapy have an antiproliferative effect on the blood-forming bone marrow?
Experimental Hematology, rok: 1998, ročník: 26, vydání: 4
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Fast detection of a (CA)(18) microsatellite repeat in the IgE receptor gene by capillary electrophoresis with laser induced fluorescence detection
Electrophoresis, rok: 1998, ročník: 19, vydání: 2
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Frequency of the Leiden mutation and the promotor variant 4G/5G of PAI-1 gene among woman with pregnancy-induced hypertension.
Scripta Medica, rok: 1998, ročník: 71, vydání: 1