Informace o projektu
Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob
- Kód projektu
- VS96097
- Období řešení
- 7/1996 - 12/2000
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Posílení výzkumu na vysokých školách
- Fakulta / Pracoviště MU
- Lékařská fakulta
An extensive study is realized in the framework of the VS 96 097 grant on the expected association between the allelic variants of selected candidate genes with several multigenic common diseases, possibly with their intermediate phenotypes.A "case-control" study research strategy is based on population studies of the genetic polymorphisms of selected candidate genes and the search of the temptative associations of the allelic frequencies with some common "civilization" diseases,as essential hypertension, diabetes mellitus (late complications thereof), atopic diseases and with the propensity of malignant tumors to form metastases. The associations are tested by means of multivariational statistical methods.It can be expected that discovering of genetically profiled subsets of patients will enable to achieve more focused prevention and treatment of the disease studied.
Publikace
Počet publikací: 74
1998
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Genetic polymorphism of RAGE and diabetic late skin complications
Pathophysiology, rok: 1998, ročník: 5, vydání: Suppl. 1
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Genotype combinations of I/D ACE and angiotensinogen genes are associated with type A behavior pattern score
The Fifth International Congress of Behavioral Medicine, rok: 1998
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Interaction of genetic variability of the genes for angiotensinogen and endothelin-1 at the onset of essential hypertension
13th Congress of Pathological and Clinical Physiology. Abstracts, rok: 1998
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Is I/D ACE gene polymorphism age-dependent?
Behav. Pharmacol., rok: 1998, ročník: 9, vydání: Suppl. 1
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Polymorphism in Genes Coding for Angiotensinogen and Endothelin-1 in Relation to Atopic Diseases
Scripta medica, rok: 1998, ročník: 71, vydání: 6-7
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Relation of polymorphisms in apolipoproteins B, E and plasminogen activator inhibitor-1 to coronary artery disease in men
13th Congress of Pathol. Clin. Physiol. Abstracts. Brno, rok: 1998
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The effect of the first hundred
Behav. Pharmacol., rok: 1998, ročník: 9, vydání: Suppl. 1
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The study of association of polymorphism of TNFbeta with ischemic heart disease
13th Congress of Pathological and Clinical Physiology, rok: 1998
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Three gene polymorphisms at psoriasis vulgaris.
Journal of the European Academy of Dermatology, rok: 1998, ročník: 11, vydání: Suppl. 2
1997
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A contribution to the statistical analysis of 24-h blood pressure and heart rate monitoring
Scripta medica, rok: 1997, ročník: 70, vydání: 2-3