Informace o projektu
Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob
- Kód projektu
- VS96097
- Období řešení
- 7/1996 - 12/2000
- Investor / Programový rámec / typ projektu
-
Ministerstvo školství, mládeže a tělovýchovy ČR
- Posílení výzkumu na vysokých školách
- Fakulta / Pracoviště MU
- Lékařská fakulta
An extensive study is realized in the framework of the VS 96 097 grant on the expected association between the allelic variants of selected candidate genes with several multigenic common diseases, possibly with their intermediate phenotypes.A "case-control" study research strategy is based on population studies of the genetic polymorphisms of selected candidate genes and the search of the temptative associations of the allelic frequencies with some common "civilization" diseases,as essential hypertension, diabetes mellitus (late complications thereof), atopic diseases and with the propensity of malignant tumors to form metastases. The associations are tested by means of multivariational statistical methods.It can be expected that discovering of genetically profiled subsets of patients will enable to achieve more focused prevention and treatment of the disease studied.
Publikace
Počet publikací: 74
1999
-
Effect of one year antihypertensive therapy with angiotensin I converting enzyme (ACE) inhibitor on hemodynamic, hematological and biochemical parameters. Effects of I/D ACE and M235T and T174M angiotensinogen gene polymorphisms
Scripta medica, rok: 1999, ročník: 72, vydání: 2-3
-
Five gene polymorphism in T-cell lymphoma
Journal of the European Academy of Dermatology and Venerology, rok: 1999, ročník: 1999, vydání: 12
-
Interaction of five gene polymorphism at psoriasis
The Journal of Investigative Dermatology, rok: 1999, ročník: 113, vydání: 3
-
Molecular variants of renin-angiotensin system genes and endothelin-1 gene in Czech men with coronary artery disease.
Cor et Vasa, rok: 1999, ročník: 41, vydání: 5
-
Novel polymorphisms in the gene encoding RAGE associated with diabetic microangiopathy
Physiological Research, rok: 1999, ročník: 48, vydání: Suppl 1
-
Polymorphism of the beta chain of the high affinity immunoglobulin E receptor (FcepsilonRI-beta) in South African black and white asthmatic and nonasthmatic individuals
Am.J.Respir.Crit.Care Med, rok: 1999, ročník: 160, vydání: 2
-
Polymorphisms in transporter antigen peptides (TAP1) and tumor necrosis factor (TNFbeta) genes in atopic diseases
Physiol Research, Suppl 1, rok: 1999
-
Polymorphisms in transporter antigen peptides (TAP1) and tumor necrosis factor (TNFbeta) genes in atopic diseases
Physiological Research, rok: 1999, ročník: 48, vydání: Suppl. 1
-
Relation of polymorphisms in apolipoproteins B, E, (a) and plasminogen activator inhibitior-1 genes to coronary artery disease in czech men under 55 years
Cor et Vasa, rok: 1999, ročník: 41, vydání: 5
-
Relation of polymorphisms of apolipoproteins B and E to coronary artery disease in men
Scripta Medica, rok: 1999, ročník: 1999, vydání: 2-3