Informace o projektu
Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob
- Kód projektu
- VS96097
- Období řešení
- 7/1996 - 12/2000
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Posílení výzkumu na vysokých školách
- Fakulta / Pracoviště MU
- Lékařská fakulta
An extensive study is realized in the framework of the VS 96 097 grant on the expected association between the allelic variants of selected candidate genes with several multigenic common diseases, possibly with their intermediate phenotypes.A "case-control" study research strategy is based on population studies of the genetic polymorphisms of selected candidate genes and the search of the temptative associations of the allelic frequencies with some common "civilization" diseases,as essential hypertension, diabetes mellitus (late complications thereof), atopic diseases and with the propensity of malignant tumors to form metastases. The associations are tested by means of multivariational statistical methods.It can be expected that discovering of genetically profiled subsets of patients will enable to achieve more focused prevention and treatment of the disease studied.
Publikace
Počet publikací: 74
2014
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Patients with chronic three-vessel disease in a 15-year follow-up study: genetic and non-genetic predictors of survival.
Medicine, rok: 2014, ročník: 93, vydání: 28, DOI
2010
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Ostr myokardialen infarkt s ST elevacii
Kardiologie, vydání: Vyd. 1., rok: 2010, počet stran: 20 s.
2005
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Extracellular volume regulation and growth
Medical Hypotheses, rok: 2005, ročník: 64, vydání: 2
2002
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Double heterozygote of two endothelin-1 gene polymorhisms (G8002A and -3A/-4A) is related to big endothelin levels in chronic heart failure
Experimental and Molecular Pathology, rok: 2002, ročník: 2002, vydání: 73
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Gene polymorphisms (G82S,1704G/T, 2184A/G and 2245G/A) in the receptor of advanced glycation end products (RAGE) with plaque psoriasis
Archives of Dermatological Research, rok: 2002, ročník: 294, vydání: 2
2001
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Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy
Ophthalmologica, rok: 2001, ročník: 4, vydání: 215
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Interactions of Lymphotoxin alpha (TNF-beta), Angiotensin-Converting Enzyme (ACE) and Endothelin-1 (ET-1) Gene Polymorphisms in Adult Periodontitis
J Periodontol, rok: 2001, ročník: 72, vydání: 1
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Lack of an Association of a Single Nucleotide Polymorphism in the Promoter of the Matrix Metalloproteinase-1 Gene in Czech Women with Pregnancy-Induced Hypertension.
Gynecologic and Obstetric Investigation, rok: 2001, ročník: 52, vydání: 2
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Polymorphisms 1704G/T and 2184A/G in the RAGE gene are associated with antioxidant status
Metabolism: Clinical and Experimental, rok: 2001, ročník: 50, vydání: 10
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Polymorphisms in the RAGE gene influence susceptibility to diabetes-associated microvascular dermatoses in NIDDM
Journal of Diabetes and its Complications, rok: 2001, ročník: 4, vydání: 15