Project information
Proteins in metabolism and interaction of organisms with the environment
- Project Identification
- MSM0021622413
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
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Faculty of Science
- prof. RNDr. Jaroslav Koča, DrSc.
- Other MU Faculty/Unit
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Central European Institute of Technology
- Keywords
- proteins, structure function relationships, protein complexes, proteome, metabolome
The proposal is the follow up of the previous, in our view successful, long-term research plan "Structure-Function Relationships of Biomolecules and their Role in Metabolism" studied in 1998-2004, and partly the project "Laboratory of Structure and Dynamics of Biomolecules" in the framework of program "250" studied in 1996-2000. The results of these projects were published in tens of scientific articles communicated in renowned international journals with high impact factors. The key aim was identification and characterization of low molecular weight substances involved in metabolism of bacteria and fungi with the special attention devoted to biochemical activities and the structure.
This new proposal will deal with other proteins from various organisms, for example animal proteins binding pheromones or proteins interacting with sacharides. The function and regulation of enzymes will be studied by novel methods suitable for monitoring of in vivo activity via monitoring of intracellular metabolites. We will continue to use structural methods. Keywords of the long-term research plan are protein, its function, structure, structure-function relationships and complexes of proteins. More general keywords are proteome and metabolome. The project will focus on such hot topics of current life sciences like protein/DNA interactions, synthesis of proteins on ribosome or applications of photo-labile groups for directed geometrical changes of protein-substrate complexes and regulation of enzymatic reactions.
Publications
Total number of publications: 835
2011
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Structure and specificity of a blood group oligosaccharide specific lectin from Aspergillus fumigatus
Year: 2011, type: Conference abstract
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Study of ergosterol signal pathway
Year: 2011, type: Conference abstract
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Study of RNA polymerase delta subunit unique for gram-positive bacteria
Year: 2011, type: Conference abstract
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Study of soybean-derived isoflavones metabolism in the rumen of lactating dairy cows
Year: 2011, type: Conference abstract
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STUDY OF THE CARBOHYDRATE CH/pi INTERACTIONS FAVOURABLE REGIONS IN THE CARBOHYDRATE SURROUNDINGS
Year: 2011, type: Conference abstract
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Substrate Specificity of Haloalkane Dehalogenases
Biochemical Journal, year: 2011, volume: 435, edition: 435, DOI
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Supramolecular Shuttle Based on Inclusion Complex between Cucurbit[6]uril and Bispyridinium Ethylene
Organic Letters, year: 2011, volume: 13, edition: 23, DOI
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Systematic Study of Carbohydrate-Aromatic CH-pi Dispersion Interaction by DFT and Highly Correlated Ab Initio Methods
Year: 2011, type: Conference abstract
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The Five Bacterial Lectins: PA-IL, PA-IIL, RSL, RS-IIL and CV-IIL Interactions with Diverse Animal Cells and Glycoproteins.
The Molecular Immunology of Complex Carbohydrates-3, year: 2011, number of pages: 57 s.
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The new platinum anticancer agent LA-12 induces Retinol Bionding Protein 4 in vivo
Year: 2011, type: Conference abstract