Project information
Proteins in metabolism and interaction of organisms with the environment
- Project Identification
- MSM0021622413
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
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Faculty of Science
- prof. RNDr. Jaroslav Koča, DrSc.
- Other MU Faculty/Unit
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Central European Institute of Technology
- Keywords
- proteins, structure function relationships, protein complexes, proteome, metabolome
The proposal is the follow up of the previous, in our view successful, long-term research plan "Structure-Function Relationships of Biomolecules and their Role in Metabolism" studied in 1998-2004, and partly the project "Laboratory of Structure and Dynamics of Biomolecules" in the framework of program "250" studied in 1996-2000. The results of these projects were published in tens of scientific articles communicated in renowned international journals with high impact factors. The key aim was identification and characterization of low molecular weight substances involved in metabolism of bacteria and fungi with the special attention devoted to biochemical activities and the structure.
This new proposal will deal with other proteins from various organisms, for example animal proteins binding pheromones or proteins interacting with sacharides. The function and regulation of enzymes will be studied by novel methods suitable for monitoring of in vivo activity via monitoring of intracellular metabolites. We will continue to use structural methods. Keywords of the long-term research plan are protein, its function, structure, structure-function relationships and complexes of proteins. More general keywords are proteome and metabolome. The project will focus on such hot topics of current life sciences like protein/DNA interactions, synthesis of proteins on ribosome or applications of photo-labile groups for directed geometrical changes of protein-substrate complexes and regulation of enzymatic reactions.
Publications
Total number of publications: 834
2010
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Systems biology at work
Current Opinion in Biotechnology, year: 2010, volume: 21, edition: 21
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The computational view inside the dynamical behavior of the RNA-binding motive
Year: 2010, type: Conference abstract
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The differences between small molecule crystallography and crystallography of proteins
Year: 2010, type: Conference abstract
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The key enzymes of thyroid hormone metabolism: Effects of an antidepressant drug fluoxetine
Year: 2010, type: Conference abstract
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The receiver domain of sensor histidine kinase of CKI1: its dynamic structure and binding specificity.
Year: 2010
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The role of nitric oxide in triggering of defence response by ergosterol
Year: 2010, type: Conference abstract
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The Solution Structure of the ADAR2 dsRBM-RNA Complex Reveals a Sequence-Specific Readout of the Minor Groove
CELL, year: 2010, volume: 143, edition: 2
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The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin
Angewandte Chemie International Edition, year: 2010, volume: 49, edition: 28
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Theoretical Studies on the Intermolecular Interactions of Potentially Primordial Base-Pair Analogues
Chemistry – A European Journal, year: 2010, volume: 16, edition: 10
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Understanding the NMR chemical shifts for 6-halopurines : role of structure, solvent and relativistic effects
Physical Chemistry Chemical Physics, year: 2010, volume: 12, edition: 19, DOI