Project information
Proteins in metabolism and interaction of organisms with the environment
- Project Identification
- MSM0021622413
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
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Faculty of Science
- prof. RNDr. Jaroslav Koča, DrSc.
- Other MU Faculty/Unit
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Central European Institute of Technology
- Keywords
- proteins, structure function relationships, protein complexes, proteome, metabolome
The proposal is the follow up of the previous, in our view successful, long-term research plan "Structure-Function Relationships of Biomolecules and their Role in Metabolism" studied in 1998-2004, and partly the project "Laboratory of Structure and Dynamics of Biomolecules" in the framework of program "250" studied in 1996-2000. The results of these projects were published in tens of scientific articles communicated in renowned international journals with high impact factors. The key aim was identification and characterization of low molecular weight substances involved in metabolism of bacteria and fungi with the special attention devoted to biochemical activities and the structure.
This new proposal will deal with other proteins from various organisms, for example animal proteins binding pheromones or proteins interacting with sacharides. The function and regulation of enzymes will be studied by novel methods suitable for monitoring of in vivo activity via monitoring of intracellular metabolites. We will continue to use structural methods. Keywords of the long-term research plan are protein, its function, structure, structure-function relationships and complexes of proteins. More general keywords are proteome and metabolome. The project will focus on such hot topics of current life sciences like protein/DNA interactions, synthesis of proteins on ribosome or applications of photo-labile groups for directed geometrical changes of protein-substrate complexes and regulation of enzymatic reactions.
Publications
Total number of publications: 835
2006
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Identification of Tunnels in Proteins, Nucleic Acids, Inorganic Materials and Molecular Ensembles.
Biotechnology Journal, year: 2006, volume: 1/2006, edition: 1
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INTEGRATION OF SHORT-END INJECTION PROCEDURE INTO EMMA METHODOLOGY
Book of abstract 15th International Symposium on Capillary Electroseparation Techniques (ITP-2006), year: 2006
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Interference of chlorate and chlorite with nitrate reduction in resting cells of Paracoccus denitrificans
Microbiology-SGM, year: 2006, volume: 152, edition: 12
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Kombinace metody EMMA s technikou dávkování z krátkého konce kapiláry
Proceeding of 15th International Conference "Chromatographic Methods and Human Health", year: 2006
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"Lock and key" recognition in the world of protein-RNA interactions: How ADAR2 binds RNA
Year: 2006, type: R&D Presentation
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"Lock and key" recognition in the world of protein-RNA interactions: How ADAR2 binds RNA
xxx, year: 2006
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MD/DFT STUDY OF ENVIRONMENTAL EFFECTS ON 31P CHEMICAL SHIFT TENSORS IN B-DNA
Materials Structure in Chemistry, Biology, Physics and Technology, year: 2006, volume: 13, edition: 1
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Measurement of Long Range 1H-19F Scalar Coupling Constants and their Glycosidic Torsion Dependence in 5-Fluoropyrimidine Substituted RNA.
Journal of the American Chemical Society, year: 2006, volume: 128, edition: 17
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Mechanism of action of anticancer titanocene derivatives: an insight from quantum chemical calculations
Journal of Physical Chemistry B, year: 2006, volume: 110/2006, edition: 39
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Microwaves in Photochemistry
Microwaves in Organic Synthesis, edition: Vyd. 2, year: 2006, number of pages: 37 s.