Project information
Proteins in metabolism and interaction of organisms with the environment
- Project Identification
- MSM0021622413
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
-
Faculty of Science
- prof. RNDr. Jaroslav Koča, DrSc.
- Other MU Faculty/Unit
-
Central European Institute of Technology
- Keywords
- proteins, structure function relationships, protein complexes, proteome, metabolome
The proposal is the follow up of the previous, in our view successful, long-term research plan "Structure-Function Relationships of Biomolecules and their Role in Metabolism" studied in 1998-2004, and partly the project "Laboratory of Structure and Dynamics of Biomolecules" in the framework of program "250" studied in 1996-2000. The results of these projects were published in tens of scientific articles communicated in renowned international journals with high impact factors. The key aim was identification and characterization of low molecular weight substances involved in metabolism of bacteria and fungi with the special attention devoted to biochemical activities and the structure.
This new proposal will deal with other proteins from various organisms, for example animal proteins binding pheromones or proteins interacting with sacharides. The function and regulation of enzymes will be studied by novel methods suitable for monitoring of in vivo activity via monitoring of intracellular metabolites. We will continue to use structural methods. Keywords of the long-term research plan are protein, its function, structure, structure-function relationships and complexes of proteins. More general keywords are proteome and metabolome. The project will focus on such hot topics of current life sciences like protein/DNA interactions, synthesis of proteins on ribosome or applications of photo-labile groups for directed geometrical changes of protein-substrate complexes and regulation of enzymatic reactions.
Publications
Total number of publications: 835
2006
-
Srs2 protein and its multi-functional role in recombination/repair processes
Year: 2006, type: R&D Presentation
-
Stanovení adeninových nukleotidů a koenzymů za pomocí CZE s využití on-line prekoncentrační techniky field enhanced stacking
Year: 2006, type: Conference abstract
-
Stanovení aktivity isoformy CYP450 2C9 pomocí micelární elektrokinetické chromatografie
X. pracovní setkání biochemiků a molekulárních biologů., year: 2006
-
Stereochemistry influence on proton transfer in protonated tripeptide model
JOURNAL OF PEPTIDE SCIENCE, year: 2006, volume: 12, edition: 2
-
Structural and evolutionary classification of G/U wobble basepairs in the ribosome
Nucleic Acids Research, year: 2006, volume: 34, edition: 5
-
Structure and dynamics of functional RNAs: 3 microseconds of explicit solvent MD
2006 ISQBP president's meeting, year: 2006
-
Structure and dynamics of ribosomal RNA: The role of molecular interactions
2006 IBBI, year: 2006
-
Structure and dynamics of RNA and DNA. Advanced computational studies.
Materials Structure in chemistry, biology, physics and technology, year: 2006
-
Structure and Specific RNA Binding of ADAR2 Double-Stranded RNA Binding Motifs
Structure, year: 2006, volume: 14, edition: 2
-
Structure and specific RNA-binding of ADAR2 double-stranded RNA-binding motifs
Year: 2006, type: R&D Presentation