Project information
Proteins in metabolism and interaction of organisms with the environment
- Project Identification
- MSM0021622413
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
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Faculty of Science
- prof. RNDr. Jaroslav Koča, DrSc.
- Other MU Faculty/Unit
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Central European Institute of Technology
- Keywords
- proteins, structure function relationships, protein complexes, proteome, metabolome
The proposal is the follow up of the previous, in our view successful, long-term research plan "Structure-Function Relationships of Biomolecules and their Role in Metabolism" studied in 1998-2004, and partly the project "Laboratory of Structure and Dynamics of Biomolecules" in the framework of program "250" studied in 1996-2000. The results of these projects were published in tens of scientific articles communicated in renowned international journals with high impact factors. The key aim was identification and characterization of low molecular weight substances involved in metabolism of bacteria and fungi with the special attention devoted to biochemical activities and the structure.
This new proposal will deal with other proteins from various organisms, for example animal proteins binding pheromones or proteins interacting with sacharides. The function and regulation of enzymes will be studied by novel methods suitable for monitoring of in vivo activity via monitoring of intracellular metabolites. We will continue to use structural methods. Keywords of the long-term research plan are protein, its function, structure, structure-function relationships and complexes of proteins. More general keywords are proteome and metabolome. The project will focus on such hot topics of current life sciences like protein/DNA interactions, synthesis of proteins on ribosome or applications of photo-labile groups for directed geometrical changes of protein-substrate complexes and regulation of enzymatic reactions.
Publications
Total number of publications: 835
2006
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Structure, Dynamics, and Elasticity of Free 16S rRNA Helix 44 Studied by Molecular Dynamics Simulations
Biopolymers, year: 2006, volume: 82, edition: 5
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Structures and mechanisms of glycosyltransferases
Glycobiology, year: 2006, volume: 16, edition: 2
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Structures and Roles of Pseudomonas aeruginosa Lectins
Protein-carbohydrate interactions in infectious diseases, year: 2006, number of pages: 19 s.
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Study of recombinant cytochrome P450 2C9 activity with diclofenac by micellar electrokinetic capillary chromatography
CD of the abstracts of the 29th international symposium on capillary chromatography, year: 2006
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Substituted purines: Experimental and theoretical study of NMR parameters
Year: 2006, type: Conference abstract
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Synthesis and tautomerism study of 7-substituted pyrazolo[3,4-c]pyridines
Tetrahedron, year: 2006, volume: 62, edition: 51
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SYSTEMIC RESISTANCE OF PLANTS, THEORY VS. PRACTICE
Year: 2006, type: Conference abstract
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TEACHING BIOCHEMISTRY AT FACULTY OF SCIENCE IN BRNO
Sborní abstrakt XX. biochemického sjezdu, year: 2006
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The association between high-activity COMT allele and alcoholism
Neuroendocrinology Letters, year: 2006, volume: 27, edition: 1
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The association of monoamine oxidase B functional polymorphism with postoperative pain intensity
Neuroendocrinology Letters, year: 2006, volume: 27, edition: 3