Project information
Biomolecular centre
- Project Identification
- LC06030
- Project Period
- 3/2006 - 12/2011
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Basic Research Center
- MU Faculty or unit
-
Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
- Keywords
- Cancer drugs, biosensors, lectins, molecular modeling of biomolecules, biomolecular NMR
- Cooperating Organization
-
Institute of Biophysics
- Responsible person prof. RNDr. Jiří Šponer, DrSc.
- Responsible person doc. RNDr. Ivan Rychlík, Ph.D.
The main goal of the project is to elevate the structural biology in the Czech Republic from studies of individual biomacromolecules to investigations of their complexes. This goal will be achieved by implementation of up-to-date methodology in selected scientific fields (NMR spectroscopy, computational modeling) and by focusing on problems, which are currently in the centre of interest of contemporary life sciences. Among others, key cell processes such as preservation of genome stability and DNA repair, ribosomal protein synthesis, or information transfer by recognition (lectins) will be studied. Selected research projects will lead eventually to bioanalytical (biosensors) and biomedical (vaccines, chemotherapeutics) outcomes with potential applications in research and development. To reach the outlined goals, active collaboration of participating institutions is inevitable. A number of projects will require also a broad international collaboration.
Results
The main goal of the project is to help to drive structural biology in the Czech Republic from studies on single biomacromolecules to studies on biomacromolecular complexes. To achieve the goal, we will implement recent advances in selected key methods in the field (NMR spectrometry, computer modeling) and also contribute to their development. The research will be oriented not only to the structure of biomacromolecules but will also include studies of structure/function relationship. It will touch suchimportant phenomena of the cell life as keeping genome stability, DNA repair, protein synthesis in the ribosome or information transfer via recognition (lectins). Selected parts of the research will be devoted to bioanalytical (biosensors) or biomedicinal(vaccines, chemotherapeutics) projects capable of providing results with potential applications at the practical level. By solving the above scientific tasks, the team will increase its international competitiveness. At the same time, the project will
Publications
Total number of publications: 284
2009
-
Analyzing and modelling thermodynamics; the key to lectin engineering
Cukrblik 2009, year: 2009
-
Aspergillus fumigatus host-interacting proteins - potential therapeutic targets
Year: 2009, type: Conference abstract
-
Backbone 1H, 13C, and 15N NMR assignment for the inactive form of the retroviral protease of the murine intracisternal A-type particle, inMIA-14 PR
Biomolecular NMR Assignments, year: 2009, volume: 3, edition: 2
-
Balance of Attraction and Repulsion in Nucleic Acid Base Stacking: CCSD(T)/Complete Basis Set Limit Calculations on Uracil Dimer and a Comparison with the Force Field Description
Journal of Chemical Theory and Computation, year: 2009, volume: 5, edition: 1
-
Burkholderia cenocepacia and its novel two domain superlectin
the FEBS Journal, year: 2009
-
Burkholderia cenocepacia lectin with dual binding specificity
Year: 2009, type: Conference abstract
-
C-13 Chemical Shifts – Structure Relationships In Nucleic Acids
Year: 2009, type: Conference abstract
-
Central European NMR Meeting - 24th NMR Valtice
Year: 2009, type: Conference
-
Classification and energetics of the base-phosphate interactions in RNA
Nucleic Acids Research, year: 2009, volume: 37, edition: 15
-
Construction of mutant lectins from Chromobacterium violaceum and study of changes in their binding properties
Year: 2009, type: Conference abstract