Project information
Biomolecular centre
- Project Identification
- LC06030
- Project Period
- 3/2006 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Basic Research Center
- MU Faculty or unit
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Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
- Keywords
- Cancer drugs, biosensors, lectins, molecular modeling of biomolecules, biomolecular NMR
- Cooperating Organization
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Institute of Biophysics
- Responsible person prof. RNDr. Jiří Šponer, DrSc.
- Responsible person doc. RNDr. Ivan Rychlík, Ph.D.
The main goal of the project is to elevate the structural biology in the Czech Republic from studies of individual biomacromolecules to investigations of their complexes. This goal will be achieved by implementation of up-to-date methodology in selected scientific fields (NMR spectroscopy, computational modeling) and by focusing on problems, which are currently in the centre of interest of contemporary life sciences. Among others, key cell processes such as preservation of genome stability and DNA repair, ribosomal protein synthesis, or information transfer by recognition (lectins) will be studied. Selected research projects will lead eventually to bioanalytical (biosensors) and biomedical (vaccines, chemotherapeutics) outcomes with potential applications in research and development. To reach the outlined goals, active collaboration of participating institutions is inevitable. A number of projects will require also a broad international collaboration.
Results
The main goal of the project is to help to drive structural biology in the Czech Republic from studies on single biomacromolecules to studies on biomacromolecular complexes. To achieve the goal, we will implement recent advances in selected key methods in the field (NMR spectrometry, computer modeling) and also contribute to their development. The research will be oriented not only to the structure of biomacromolecules but will also include studies of structure/function relationship. It will touch suchimportant phenomena of the cell life as keeping genome stability, DNA repair, protein synthesis in the ribosome or information transfer via recognition (lectins). Selected parts of the research will be devoted to bioanalytical (biosensors) or biomedicinal(vaccines, chemotherapeutics) projects capable of providing results with potential applications at the practical level. By solving the above scientific tasks, the team will increase its international competitiveness. At the same time, the project will
Publications
Total number of publications: 284
2009
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Electron Density Shift in Imidazolium Derivatives upon Complexation with Cucurbit[6]uril
Chemistry - A European Journal, year: 2009, volume: 15, edition: 28, DOI
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Experimental and quantum-chemical studies of 1H, 13C and 15N NMR coordination shifts in Au(III), Pd(II) and Pt(II) chloride complexes with picolines
Magnetic Resonance in Chemistry, year: 2009, volume: 47, edition: 3
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Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption.
Nucleic Acids Research, year: 2009, volume: 20, edition: 37
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Charge Localization on Imidazolium Ring upon Complexation with Cucurbit[6]uril
Year: 2009, type: Conference abstract
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Implementation and Testing of Multiple Walkers Approach Based Free Energy Calculations in the Grid Environment
GCCP Proceedings, year: 2009
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Implementation of Parallel Analyzes of Molecular Dynamics Simulation Trajectories
Year: 2009, type: Conference abstract
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Importance of oligomerisation on Pseudomonas aeruginosa Lectin-II binding affinity. In silico and in vitro mutagenesis.
Journal of Molecular Modeling, year: 2009, volume: 15, edition: 6
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Investigating effect of ionic strength on conformational behavior of beta amyloids
Year: 2009, type: Conference abstract
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Investigation of mutation-induced binding preference changes of CV-IIL lectin
Year: 2009, type: Conference abstract
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Investigation of Thermal Denaturation of Barley Nonspecific Lipid Transfer Protein 1 (ns-LTP1b) by Nuclear Magnetic Resonance and Differential Scanning Calorimetry
Journal of Agricultural and Food Chemistry, year: 2009, volume: 57, edition: 18