Project information
Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
- Project Identification
- MSM0021622430
- Project Period
- 1/2007 - 12/2013
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Other MU Faculty/Unit
- Faculty of Informatics
- Other MU Faculty/Unit
- Central European Institute of Technology
- Keywords
- embryonic stem cells
The goal of this project will be a) to profit from availability of unique cellular resources - mouse and human embryonic stem cells and normal and malignant hematopoietic stem/progenitor cells, b) to effectively employ a wide variety of current and complementary methodologies available to the consortium, and c) to exploit a proven/certified expertise in working with various living systems that span from in vitro cultured cells, through animal models to oncohematological patients. All this together will represent a powerful experimental platform aimed at addressing a nature of molecules and molecular mechanisms underlaying phenomena that are common to both normal and cancer stem cells, mainly their ability to self-renew and to enter differentiation pathways. Integral part of this general goal is to implement multifaceted analytical approach that will cover studies of gene expression at both mRNA and protein levels, evaluating function of extra and intracellular signaling pathways, and analyzing biological properties of cells in vitro and in vivo. Expected outcome will be not only understanding but also a definition of molecules and/or molecular pathways to be tested as therapeutic targets, and cellular models that will make such testing feasible.
Publications
Total number of publications: 357
2012
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Sixteen years and counting: the current understanding of fibroblast growth factorreceptor 3 (FGFR3) signaling in skeletal dysplasias.
Human Mutation, year: 2012, volume: 33, edition: 1, DOI
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Srovnání kinetiky mutací v genech IDH2 a NPM1 metodou kvantitativní RQ-PCR u pacientů s akutní myloidní leukémií (AML).
Year: 2012, type: Conference abstract
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T315I mutations are clustered with advanced phases contrary to other aberrations in CML patients resistant to TKI therapy
Year: 2012, type: Conference abstract
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Treatment of molecular relapse in patients with acute myeloid leukemia using clofarabine monotherapy
American Journal of Hematology, year: 2012, volume: 87, edition: 2, DOI
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Tumor dynamics of chronic lymphocytic leukemia cases with multiple productive IGHV-IGHD-IGHJ rearrangement
Year: 2012, type: Conference abstract
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Úloha microRNA v regulaci signalizace přes b-buněčný receptor a jejich vztah k patogenezi chronické lymfocytární leukémie (CLL)
Year: 2012, type: Conference abstract
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"ULTRA-DEEP" sekvenování identifikuje TP53 mutace před jejich klonální selekcí léčbou u chronické lymfocytární leukémie
Year: 2012, type: Conference abstract
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Understanding cell-to-cell communication in hESCs - creating basis for the move to 3D culture.
Year: 2012, type: Conference abstract
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Understanding cell-to-cell communication in hESCs - creating basis for the move to 3D culture.
Year: 2012, type: Appeared in Conference without Proceedings
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Způsob stanovení závažnosti a prognózy B-buněčné chronické lymfocytární leukémie
Publisher: , state: Czech Republic, patent's number: 303555, year: 2012