Project information
Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
- Project Identification
- MSM0021622430
- Project Period
- 1/2007 - 12/2013
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Other MU Faculty/Unit
- Faculty of Informatics
- Other MU Faculty/Unit
- Central European Institute of Technology
- Keywords
- embryonic stem cells
The goal of this project will be a) to profit from availability of unique cellular resources - mouse and human embryonic stem cells and normal and malignant hematopoietic stem/progenitor cells, b) to effectively employ a wide variety of current and complementary methodologies available to the consortium, and c) to exploit a proven/certified expertise in working with various living systems that span from in vitro cultured cells, through animal models to oncohematological patients. All this together will represent a powerful experimental platform aimed at addressing a nature of molecules and molecular mechanisms underlaying phenomena that are common to both normal and cancer stem cells, mainly their ability to self-renew and to enter differentiation pathways. Integral part of this general goal is to implement multifaceted analytical approach that will cover studies of gene expression at both mRNA and protein levels, evaluating function of extra and intracellular signaling pathways, and analyzing biological properties of cells in vitro and in vivo. Expected outcome will be not only understanding but also a definition of molecules and/or molecular pathways to be tested as therapeutic targets, and cellular models that will make such testing feasible.
Publications
Total number of publications: 357
2011
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Detection of clonal evolution and subclonal heterogeneity in chronic lymphocytic leukemia using deep sequencing of antioncogene TP53
Year: 2011, type: Conference abstract
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Double/Triple productive immunoglobulin rearrangements in chronic lymphocytic leukemia patients
Year: 2011, type: Conference abstract
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Evaluation of TP53 mutations in chronic lymphocytic leukemia using resequencing microarray platforms
Year: 2011, type: Conference abstract
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Expression of death receptors in human embryonic stem cells and their differentiated derivatives
Year: 2011, type: Conference abstract
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Gene expression based classification of non-Hodgkin lymphomas
Year: 2011, type: Conference abstract
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Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands
TOXICOLOGY LETTERS, year: 2011, volume: 206, edition: 2, DOI
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Gene expression profiling in follicular lymphoma and its implication for clinical practise
LEUKEMIA & LYMPHOMA, year: 2011, volume: 52, edition: 1, DOI
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Genově-expresní profil leukemických pacientů s akutní reakcí štěpu proti hostiteli s využitím microarray analýzy
Year: 2011, type: Conference abstract
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Geranylated flavanone tomentodiplacone B inhibits proliferation of human monocytic leukaemia (THP-1) cells.
British Journal of Pharmacology, year: 2011, volume: 162, edition: 7, DOI
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Human embryonic stem cell-derived lung epithelial cells in vitro and in vivo
Year: 2011, type: Conference abstract