Project information
Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
- Project Identification
- MSM0021622430
- Project Period
- 1/2007 - 12/2013
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Other MU Faculty/Unit
- Faculty of Informatics
- Other MU Faculty/Unit
- Central European Institute of Technology
- Keywords
- embryonic stem cells
The goal of this project will be a) to profit from availability of unique cellular resources - mouse and human embryonic stem cells and normal and malignant hematopoietic stem/progenitor cells, b) to effectively employ a wide variety of current and complementary methodologies available to the consortium, and c) to exploit a proven/certified expertise in working with various living systems that span from in vitro cultured cells, through animal models to oncohematological patients. All this together will represent a powerful experimental platform aimed at addressing a nature of molecules and molecular mechanisms underlaying phenomena that are common to both normal and cancer stem cells, mainly their ability to self-renew and to enter differentiation pathways. Integral part of this general goal is to implement multifaceted analytical approach that will cover studies of gene expression at both mRNA and protein levels, evaluating function of extra and intracellular signaling pathways, and analyzing biological properties of cells in vitro and in vivo. Expected outcome will be not only understanding but also a definition of molecules and/or molecular pathways to be tested as therapeutic targets, and cellular models that will make such testing feasible.
Publications
Total number of publications: 358
2010
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Sledování mutací v exonu 4 genů IDH1 a IDH2 u pacientů s akutní myeloidní leukémií
Year: 2010, type: Conference abstract
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Stanovení intracelulární koncentrace imatinibu u CML pacientů
Year: 2010, type: Conference abstract
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Subklasifikace ne-Hodgkinských lymfomů pomocí cílených DNA čipů
Year: 2010, type: Conference abstract
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Targeting integrin/CD49D/VLA-4 with natalizumab can inhibit adhesion of malignant B cells and sensitize them to chemoimmunotherapy
Year: 2010, type: Conference abstract
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The assessment of human organic cation transporter 1 (hOCT1) mRNA expression in patients with chronic myelogenous leukemia is affected by the proportion of different cells types in the analyzed cell population
American Journal of Hematology, year: 2010, volume: 85, edition: 7, DOI
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The role of Cdk5 in Human Embryonic Stem Cells
Year: 2010, type: Conference abstract
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The role of chromatin condensation during granulopoiesis in the regulation of gene cluster expression
Epigenetics, year: 2010, volume: 5, edition: 8, DOI
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Time lapse living cells microscopy for studying CML: Preparation of Abl1- and Bcr/Abl - fluorescent protein vectors using Gateway technology
Advances in Molecular and Cancer Biology, 2010, year: 2010
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To divide or not to divide? How human embryonic stem cells deal with extra chromosomes?
Year: 2010, type: Appeared in Conference without Proceedings
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Too much of a good thing can harm: deregulation of centrosome number in human embryonic stem cells
Year: 2010, type: Conference abstract