Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2002
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Ochrana proti válečným a mírovým škodlivinám VI. Ochranné oděvy pro jedno použití a improvizované prostředky
Rescue Report, year: 2002, volume: 5, edition: 6
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Old scrap chemical munitions and toxic armaments wastes in the Central-European and Baltic regions
SECOTOX EAST 02: Trends and Advances in Environmental Chemistry and Ecotoxicology, Book of abstracts, year: 2002
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Old scrap chemical munitions and toxic armaments wastes in the Central-European and Baltic regions.
SECOTOX EAST 02: Trends and Advances in Environmental Chemistry and Ecotoxicology, Brno 2002. Book of abstracts, year: 2002
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Our experience with the treatment of malignant liver tumours
Mini-Invasive approach to Cancer, year: 2002
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PCBs in aquatic ecosystems of the river Elbe and Berlin waters
Book of Abstracts - The 2nd PCB Workshop: Recent Advances in the Environmental Toxicology and Health Effects of PCBs Emphasis on the latest advances and the perspective of Central and Eastern Europe. Brno, CR, 07-11/05/2002, year: 2002
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PCBs in the environment of Slovenia and Croatia as consequence of their accidental release
Book of Abstracts - The 2nd PCB Workshop: Recent Advances in the Environmental Toxicology and Health Effects of PCBs Emphasis on the latest advances and the perspective of Central and Eastern Europe. Brno, CR, 07-11/05/2002, year: 2002
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Persistent organic pollutants in global environment:Stockholm Convention (2001) and problems of its implementation.
2nd Meeting on Chemistry and Life, year: 2002
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Persistent organic pollutants in the global environment: Stockholm Convention (2002) and problems of its implementation
Chemické listy, year: 2002, volume: 96, edition: 1
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Persistent organic pollutants in the global environment: Stockholm Convention (2001) and problems of its implementation.
54. Sjezd chemických společností, year: 2002
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Persistent organic pollutants in the global environment:Stockholm Convention and problems of its implementation
Chemické listy, year: 2002, volume: 96, edition: 1