Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2002
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Personal decontamination at emergencies
The 4th International Chemical and Biological Medical Treatment Symposium, Spiez 2002. Abstract of Presentations, year: 2002
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Personal Decontamination at Chem Demil operations
The International CW Demil Conference CWD 02, The Hague 2002, Conference Abstracts, year: 2002
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Personal decontamination within the rescue measures following terrorist chemical, biological and radiological attacks
NATO-ARW: Technology for Combating WMD Terrorism , Baltimore - Hunt Valley 2002. Abstract Digest, year: 2002
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Pleural effusion in advanced cancer patients hospitalized at the department of paliative care
European Journal of Palliative Care, year: 2002
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Polyhalogendibenzo-p-dioxiny a dibenzofurany nejtoxičtější nízkomolekulární syntetické jedy
Seminář Odborné skupiny toxikologické chemie, ČSCH, year: 2002
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Polyvalent technology for the NBC-decontamination of heavy, large-size and sensitive equipment items
2nd Symposium on NBC-Decontamination, year: 2002
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POPs Enabling activities to facilitate early action in the implementation of the Stockholm Convention on Persistent Organic Pollutants in the Czech Republic
SECOTOX East 2002, 7th Regional Meeting of the Central and Eastern European Section, Trends and Advances In Environmental Chemistry and Ecotoxicology, Book of Abstracts, year: 2002
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Prognostické faktory karcinomu faryngu a supraglottis
Choroby hlavy a krku ( Head and Neck Diseases), year: 2002, volume: 5, edition: 1
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Projekt CARMEN - výsledky epidemiologické studie karcinomu prsu u žen v ČR
J. Abrahámová (Ed) Vybrané otázky onkologie VI., year: 2002, number of pages: 4 s.
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Randomised, double-blind comparison of efficacy and tolerability od diclofenac mouthwash versus placebo in mucositis of oral cavity by radiotherapy
Journal of Clinical Research, year: 2002, volume: 1, edition: 5