Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2001
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Optimisation of porcine hepatocyte cryopreservation by comparison of viability and enzymatic activity of fresh and cryopreserved cells
Acta veterinaria (Brno), year: 2001, volume: 70, edition: 2
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Persistent, Bioaccumulative and Toxic Compounds in the Central and Eastern European Countries - State-of-the-Art Report - hot spots
Arch. Industr. Hyg. Toxicol., year: 2001, volume: 52, edition: 2
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Persistent, Bioaccumulative and Toxic Compounds in the Central and Eastern European Countries - State-of-the-Art Report - human exposure
Arch. Industr. Hyg. Toxicol., year: 2001, volume: 52, edition: 2
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Personal protection of decontamination and rescue teams engaged following to terrorist chemical and biological strikes
The 1st World Congress on Chemical and Biological Terrorism (CBMTS Industry II), year: 2001
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Pneumocystis carinii pneumonia (PCP) in HIV negative patients
European Respiratory Journal, year: 2001
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Possibilities of detection and early warning in case of terrorist chemical attacks in subways.
The 1st World Congress on Chemical and Biological Terrorism (CBMTS Industry II), year: 2001
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Použití INT jako chromogenu při stanovení organofosforových sloučenin metodou inhibice cholinesteráz s thiocholinovými substráty
XIV Celostátní seminář o separační chemii a analýze toxických látek, year: 2001
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Predikce rizika vzniku karcinomu prsu u žen v České republice - metodika sběru dat pro validaci matematického prediktivního modelu
Klinická Onkologie, year: 2001, volume: 4, edition: 1
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Project IDRIS - Ecological Risk Assessment - regional approaches
Assessment and Management of Environmental Risks: Cost-Efficient Methods and Applications, year: 2001, number of pages: 11 s.
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Projekt CARMEN - iniciativa v oblasti výzkumu, edukace a prevence karcinomu prsu
Vybrané otázky onkologie, edition: Vyd. V., year: 2001, number of pages: 3 s.