Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2001
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Rozdělení hexachlorbenzenu mezi půdu a atmosféru. Validace modelu a výpočtu pomocí SPME
OVZDUŠÍ 2001 - Program a sborník konference, year: 2001
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Seasonal variation in estrogen and progesterone receptor levels in breast cancer - a factor in data interpretation
Neoplasma, year: 2001, volume: 48, edition: 1
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Smlouva o všeobecném zákazu jaderných zkoušek.
Mezinárodní politika, year: 2001, volume: 25, edition: 8
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Softwarový standard analýz dat Národního onkologického registru - model karcinomu prsu
Vybrané otázky onkologie, edition: Vyd. V., year: 2001, number of pages: 4 s.
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Stimulation of nonspecific immunity, haemopoiesis and protection of mice against radiation injury by 1-adamntylamide-L-alanyl-D-isoglutamine incorporated in liposomes
International Immunopharmacology, year: 2001, volume: 1, edition: 1
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Superstanice EMEP - koncepční přístup
Ochrana ovzduší, year: 2001, volume: 13, edition: 1
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Suplementace hořčíku u onkologicky nemocných v průběhu chemoterapie.
Nutriční a metabolická podpora u kritických stavů a orgánového selhání, edition: Vyd. 1., year: 2001, number of pages: 3 s.
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Systém vizualizace dat Národního onkologického registru (software SVOD)
Zdravotnické noviny - Lékařské listy, year: 2001, volume: 2001, edition: 12
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The Limits of Surgical Treatment of Non-Small Cell Lung Cancer
Acta Medica Austriaca, year: 2001, volume: 2001, edition: 2
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The relationship of CD4 Th1/Th2 activity with the response of malignant melanoma patients to immunotherapy
Int J Mol Med, year: 2001, volume: 1, edition: 1