Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2001
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The use of a microbial contact toxicity test for evaluating cadmium bioavailability in soil
J. Soils and Sediments, year: 2001, volume: 1, edition: 1
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Therapeutic approaches for patients with small cell lung cancer (SCLC)
Lung Cancer, year: 2001
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Therapeutic Approaches for Patients with Small Cell Lung Cancer (SCLC)
Lung Cancer Current Topics, year: 2001, number of pages: 4 s.
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Toxicita microcystinu pro embrya kapra obecného (Cyprinus carpio, L.)
Sborník referátů konference Toxicita a biodegradabilita odpadů a látek významných ve vodním prostředí, year: 2001
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Toxické metabolity produkované mikrobiálními biofilmy vodárenských systémů
Sborník 6. konference Pitná voda 2001, year: 2001
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Toxicological and radiotoxicological problems of using anti-armour munitions containing depleted uranium core
21st International Symposium Industrial Toxicology, year: 2001
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Toxiny sinic a současná realita v ČR
SOVAK, year: 2001, volume: 10, edition: 3
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Treatment of locoregionally advanced non small cell lung cancer (NSCLC) with combined chemotherapy and concurrent radiotherapy
Lung Cancer, year: 2001
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Treatment of Locoregionally Advanced Non-Small Cell Lung Cancer (NSCLC) With Combined Chemotherapy and Concurrent Radiotherapy
Lung Cancer, year: 2001, number of pages: 4 s.
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Tumor-promoční aktivita polycyklických aromatických uhlovodíků a reálných extraktů vzorků vzduchu
OVZDUŠÍ 2001 - Program a sborník konference, year: 2001